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The Tyrosine Kinase Inhibitor Sunitinib Affects Ovulation but Not Ovarian Reserve in Mouse: A Preclinical Study

The aim of the study was to evaluate ovarian toxicity of tyrosine kinase inhibitor (TKI) sunitinib, since only scarce data are available on gonadal function after this treatment. Six-week-old female mice received orally, once daily, vehicle or sunitinib (50 mg/kg/d) during 5 weeks. Fertility paramet...

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Detalles Bibliográficos
Autores principales:	Bernard, Valérie, Bouilly, Justine, Kramer, Piet, Carré, Nadège, Schlumberger, Martin, Visser, Jenny A., Young, Jacques, Binart, Nadine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818017/ https://www.ncbi.nlm.nih.gov/pubmed/27035144 http://dx.doi.org/10.1371/journal.pone.0152872

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