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Transcriptional profiling of macrophage and tumor cell interactions in vitro
Macrophages are important mediators of tumor progression and their function is broadly influenced by different microenvironmental stimuli. To understand the molecular basis of the tumor-supporting role of macrophages in aggressive breast cancer we co-cultured human peripheral monocytes with two brea...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818341/ https://www.ncbi.nlm.nih.gov/pubmed/27081631 http://dx.doi.org/10.1016/j.gdata.2016.02.009 |
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author | Roudnicky, Filip Hollmén, Maija |
author_facet | Roudnicky, Filip Hollmén, Maija |
author_sort | Roudnicky, Filip |
collection | PubMed |
description | Macrophages are important mediators of tumor progression and their function is broadly influenced by different microenvironmental stimuli. To understand the molecular basis of the tumor-supporting role of macrophages in aggressive breast cancer we co-cultured human peripheral monocytes with two breast cancer cell lines representing distinct aggressive cellular phenotype and transcriptionally profiled the changes occurring in both cells during in vitro activated crosstalk. Here we provide a detailed description of the experimental design, sample identity and analysis of the Illumina RNA-Seq data, which have been deposited into Gene Expression Omnibus (GEO): GSE75130. |
format | Online Article Text |
id | pubmed-4818341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-48183412016-04-14 Transcriptional profiling of macrophage and tumor cell interactions in vitro Roudnicky, Filip Hollmén, Maija Genom Data Data in Brief Macrophages are important mediators of tumor progression and their function is broadly influenced by different microenvironmental stimuli. To understand the molecular basis of the tumor-supporting role of macrophages in aggressive breast cancer we co-cultured human peripheral monocytes with two breast cancer cell lines representing distinct aggressive cellular phenotype and transcriptionally profiled the changes occurring in both cells during in vitro activated crosstalk. Here we provide a detailed description of the experimental design, sample identity and analysis of the Illumina RNA-Seq data, which have been deposited into Gene Expression Omnibus (GEO): GSE75130. Elsevier 2016-02-22 /pmc/articles/PMC4818341/ /pubmed/27081631 http://dx.doi.org/10.1016/j.gdata.2016.02.009 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Data in Brief Roudnicky, Filip Hollmén, Maija Transcriptional profiling of macrophage and tumor cell interactions in vitro |
title | Transcriptional profiling of macrophage and tumor cell interactions in vitro |
title_full | Transcriptional profiling of macrophage and tumor cell interactions in vitro |
title_fullStr | Transcriptional profiling of macrophage and tumor cell interactions in vitro |
title_full_unstemmed | Transcriptional profiling of macrophage and tumor cell interactions in vitro |
title_short | Transcriptional profiling of macrophage and tumor cell interactions in vitro |
title_sort | transcriptional profiling of macrophage and tumor cell interactions in vitro |
topic | Data in Brief |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818341/ https://www.ncbi.nlm.nih.gov/pubmed/27081631 http://dx.doi.org/10.1016/j.gdata.2016.02.009 |
work_keys_str_mv | AT roudnickyfilip transcriptionalprofilingofmacrophageandtumorcellinteractionsinvitro AT hollmenmaija transcriptionalprofilingofmacrophageandtumorcellinteractionsinvitro |