Novel hyaluronic acid–methotrexate conjugate suppresses joint inflammation in the rat knee: efficacy and safety evaluation in two rat arthritis models

BACKGROUND: Methotrexate (MTX) is one of the most widely used medications to treat rheumatoid arthritis (RA), and recent studies have also suggested the potential benefit of the drug for the treatment of osteoarthritis (OA) of the knee. MTX is commonly administered in oral formulations, but is often...

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Detalles Bibliográficos
Autores principales: Tamura, Tatsuya, Higuchi, Yoshinobu, Kitamura, Hidetomo, Murao, Naoaki, Saitoh, Ryoichi, Morikawa, Tadashi, Sato, Haruhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818416/
https://www.ncbi.nlm.nih.gov/pubmed/27039182
http://dx.doi.org/10.1186/s13075-016-0971-8

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