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Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain

Alterations in calcium homeostasis are widely reported to contribute to synaptic degeneration and neuronal loss in Alzheimer’s disease. Elevated cytosolic calcium concentrations lead to activation of the calcium-sensitive cysteine protease, calpain, which has a number of substrates known to be abnor...

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Detalles Bibliográficos
Autores principales:	Kurbatskaya, Ksenia, Phillips, Emma C., Croft, Cara L., Dentoni, Giacomo, Hughes, Martina M., Wade, Matthew A., Al-Sarraj, Safa, Troakes, Claire, O’Neill, Michael J., Perez-Nievas, Beatriz G., Hanger, Diane P., Noble, Wendy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818436/ https://www.ncbi.nlm.nih.gov/pubmed/27036949 http://dx.doi.org/10.1186/s40478-016-0299-2

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