Brinp1(−/−) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density

BACKGROUND: BMP/RA-inducible neural-specific protein 1 (Brinp1) is highly conserved in vertebrates, and continuously expressed in the neocortex, hippocampus, olfactory bulb and cerebellum from mid-embryonic development through to adulthood. METHODS: Brinp1 knock-out (Brinp1(−/−)) mice were generated...

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Detalles Bibliográficos
Autores principales: Berkowicz, Susan R., Featherby, Travis J., Qu, Zhengdong, Giousoh, Aminah, Borg, Natalie A., Heng, Julian I., Whisstock, James C., Bird, Phillip I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818446/
https://www.ncbi.nlm.nih.gov/pubmed/27042284
http://dx.doi.org/10.1186/s13229-016-0079-7

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