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Colony-stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis

BACKGROUND: CSF-1 or IL-34 stimulation of CSF1R promotes macrophage differentiation, activation and osteoclastogenesis, and pharmacological inhibition of CSF1R is beneficial in animal models of arthritis. The objective of this study was to determine the relative contributions of CSF-1 and IL-34 sign...

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Detalles Bibliográficos
Autores principales:	Garcia, Samuel, Hartkamp, Linda M., Malvar-Fernandez, B, van Es, Inge E., Lin, Haishan, Wong, Justin, Long, Li, Zanghi, James A., Rankin, Andrew L., Masteller, Emma L., Wong, Brian R., Radstake, Timothy R. D. J., Tak, Paul P., Reedquist, Kris A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818474/ https://www.ncbi.nlm.nih.gov/pubmed/27036883 http://dx.doi.org/10.1186/s13075-016-0973-6

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