Mitochondrial DNA damage and vascular function in patients with diabetes mellitus and atherosclerotic cardiovascular disease

OBJECTIVE: Prior studies demonstrate mitochondrial dysfunction with increased reactive oxygen species generation in peripheral blood mononuclear cells in diabetes mellitus. Oxidative stress-mediated damage to mitochondrial DNA promotes atherosclerosis in animal models. Thus, we evaluated the relatio...

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Detalles Bibliográficos
Autores principales: Fetterman, Jessica L., Holbrook, Monica, Westbrook, David G., Brown, Jamelle A., Feeley, Kyle P., Bretón-Romero, Rosa, Linder, Erika A., Berk, Brittany D., Weisbrod, Robert M., Widlansky, Michael E., Gokce, Noyan, Ballinger, Scott W., Hamburg, Naomi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818501/
https://www.ncbi.nlm.nih.gov/pubmed/27036979
http://dx.doi.org/10.1186/s12933-016-0372-y

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