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Mitochondrial DNA damage and vascular function in patients with diabetes mellitus and atherosclerotic cardiovascular disease
OBJECTIVE: Prior studies demonstrate mitochondrial dysfunction with increased reactive oxygen species generation in peripheral blood mononuclear cells in diabetes mellitus. Oxidative stress-mediated damage to mitochondrial DNA promotes atherosclerosis in animal models. Thus, we evaluated the relatio...
Autores principales: | Fetterman, Jessica L., Holbrook, Monica, Westbrook, David G., Brown, Jamelle A., Feeley, Kyle P., Bretón-Romero, Rosa, Linder, Erika A., Berk, Brittany D., Weisbrod, Robert M., Widlansky, Michael E., Gokce, Noyan, Ballinger, Scott W., Hamburg, Naomi M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818501/ https://www.ncbi.nlm.nih.gov/pubmed/27036979 http://dx.doi.org/10.1186/s12933-016-0372-y |
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