Cargando…
Cul3-KLHL20 ubiquitin ligase: physiological functions, stress responses, and disease implications
Cullin-RING ubiquitin ligases are the largest Ubiquitin ligase family in eukaryotes and are multi-protein complexes. In these complexes, the Cullin protein serves as a scaffold to connect two functional modules of the ligases, the catalytic subunit and substrate-binding subunit. KLHL20 is a substrat...
Autores principales: | Chen, Hsin-Yi, Liu, Chin-Chih, Chen, Ruey-Hwa |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818519/ https://www.ncbi.nlm.nih.gov/pubmed/27042198 http://dx.doi.org/10.1186/s13008-016-0017-2 |
Ejemplares similares
-
A synthetic KLHL20 ligand to validate CUL3(KLHL20) as a potent E3 ligase for targeted protein degradation
por: Farrell, Brian M., et al.
Publicado: (2022) -
The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A
por: Moghe, Saili, et al.
Publicado: (2011) -
The Cul3–KLHL21 E3 ubiquitin ligase targets Aurora B to midzone microtubules in anaphase and is required for cytokinesis
por: Maerki, Sarah, et al.
Publicado: (2009) -
BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress
por: Chen, Fei-Yun, et al.
Publicado: (2019) -
Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications
por: Chen, Hsin-Yi, et al.
Publicado: (2016)