Effects of conventional immunosuppressive treatment on CD244+ (CD28null) and FOXP3+ T cells in the inflamed muscle of patients with polymyositis and dermatomyositis

BACKGROUND: T-cell infiltrates may persist in muscle tissue of polymyositis (PM) and dermatomyositis (DM) patients despite aggressive immunosuppressive treatment. Here, we investigated to what extent persistent T cells in affected muscle were FOXP3+, a marker for regulatory T cells (Tregs), or CD244...

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Detalles Bibliográficos
Autores principales: Pandya, Jayesh M., Loell, Ingela, Hossain, Mohammad Shahadat, Zong, Mei, Alexanderson, Helene, Raghavan, Sukanya, Lundberg, Ingrid E., Malmström, Vivianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818535/
https://www.ncbi.nlm.nih.gov/pubmed/27039301
http://dx.doi.org/10.1186/s13075-016-0974-5

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