Thalidomide is more efficient than sodium butyrate in enhancing GATA-1 and EKLF gene expression in erythroid progenitors derived from HSCs with β-globin gene mutation

Background: Efficient induction of fetal hemoglobin (HbF) is considered as an effective therapeutic approach in beta thalassemia. HbF inducer agents can induce the expression of γ-globin gene and produce high levels of HbF via different epigenetic and molecular mechanisms. Thalidomide and sodium but...

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Detalles Bibliográficos
Autores principales: Jalali Far, Mohammad Ali, Dehghani Fard, Ali, Hajizamani, Saiedeh, Mossahebi-Mohammadi, Majid, Yaghooti, Hamid, Saki, Najmaldin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818787/
https://www.ncbi.nlm.nih.gov/pubmed/27047649

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