Mutation Detection in an Antibody-Producing Chinese Hamster Ovary Cell Line by Targeted RNA Sequencing

Chinese hamster ovary (CHO) cells have been used widely in the pharmaceutical industry for production of biological therapeutics including monoclonal antibodies (mAb). The integrity of the gene of interest and the accuracy of the relay of genetic information impact product quality and patient safety...

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Detalles Bibliográficos
Autores principales: Zhang, Siyan, Hughes, Jason D., Murgolo, Nicholas, Levitan, Diane, Chen, Janice, Liu, Zhong, Shi, Shuangping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818804/
https://www.ncbi.nlm.nih.gov/pubmed/27088091
http://dx.doi.org/10.1155/2016/8356435

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