Autocrine Sonic hedgehog signaling promotes gastric cancer proliferation through induction of phospholipase Cγ1 and the ERK1/2 pathway

BACKGROUND: Sonic hedgehog (SHH) plays critical roles in cell growth and development. Tumor cells express SHH, which can promote cell proliferation and epithelial-to-mesenchymal transition. However, the autocrine SHH pathway has not been described in gastric cancer. The aim of this study was to expl...

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Detalles Bibliográficos
Autores principales: Ertao, Zhai, Jianhui, Chen, Chuangqi, Chen, Changjiang, Qin, Sile, Chen, Yulong, He, Hui, Wu, Shirong, Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818860/
https://www.ncbi.nlm.nih.gov/pubmed/27039174
http://dx.doi.org/10.1186/s13046-016-0336-9

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