Specific pattern of maturation and differentiation in the formation of cortical tubers in tuberous sclerosis omplex (TSC): evidence from layer-specific marker expression

BACKGROUND: Tuberous sclerosis complex (TSC) is a multisystem disorder that results from mutations in the TSC1 or TSC2 genes, leading to constitutive activation of the mammalian target of rapamycin (mTOR) signaling pathway. Cortical tubers represent typical lesions of the central nervous system (CNS...

Descripción completa

Detalles Bibliográficos
Autores principales: Mühlebner, Angelika, Iyer, Anand M., van Scheppingen, Jackelien, Anink, Jasper J., Jansen, Floor E., Veersema, Tim J., Braun, Kees P., Spliet, Wim G. M., van Hecke, Wim, Söylemezoğlu, Figen, Feucht, Martha, Krsek, Pavel, Zamecnik, Josef, Bien, Christian G., Polster, Tilman, Coras, Roland, Blümcke, Ingmar, Aronica, Eleonora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818922/
https://www.ncbi.nlm.nih.gov/pubmed/27042238
http://dx.doi.org/10.1186/s11689-016-9142-0

Ejemplares similares

Ejemplares similares