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Cytomorphometric Characteristics of Buccal Mucosal Cells in Behçet's Disease Patients
Background. The aim of this study was to compare the cytomorphometric characteristics of the buccal cells of Behçet's disease patients with those of healthy controls. Methods. This case-control study compared a group of 30 patients with Behçet's disease with an age- and gender-matched cont...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819084/ https://www.ncbi.nlm.nih.gov/pubmed/27088074 http://dx.doi.org/10.1155/2016/6035801 |
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author | Aktunc, Erol Oz, Zehra Safi Bektas, Sibel Altinyazar, Cevdet Koca, Rafet Bostan, Serdar |
author_facet | Aktunc, Erol Oz, Zehra Safi Bektas, Sibel Altinyazar, Cevdet Koca, Rafet Bostan, Serdar |
author_sort | Aktunc, Erol |
collection | PubMed |
description | Background. The aim of this study was to compare the cytomorphometric characteristics of the buccal cells of Behçet's disease patients with those of healthy controls. Methods. This case-control study compared a group of 30 patients with Behçet's disease with an age- and gender-matched control group of 30 healthy individuals. The buccal mucosal smears were stained using the Papanicolaou technique for cytomorphometric analyses. The nuclear and cytoplasmic areas were evaluated using digital image analysis; the ratio of nuclear to cytoplasmic areas and nuclear roundness are presented. Results. The nuclear and cytoplasmic areas of the BD patients' cells were significantly smaller than those of the healthy controls' cells, while the nucleus-to-cytoplasm ratio and neutrophil infiltration rate did not differ significantly between the groups. However, the nuclear area, cytoplasmic area, nucleus-to-cytoplasm ratio, and nuclear roundness factor were significantly higher in patients without aphthae. The neutrophil infiltration rate did not differ significantly in patients with or without aphthae. Conclusion. Behçet's disease can produce cytomorphometric changes in buccal cells that are detectable by exfoliative cytology and cytomorphometric analysis techniques. |
format | Online Article Text |
id | pubmed-4819084 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48190842016-04-17 Cytomorphometric Characteristics of Buccal Mucosal Cells in Behçet's Disease Patients Aktunc, Erol Oz, Zehra Safi Bektas, Sibel Altinyazar, Cevdet Koca, Rafet Bostan, Serdar Anal Cell Pathol (Amst) Clinical Study Background. The aim of this study was to compare the cytomorphometric characteristics of the buccal cells of Behçet's disease patients with those of healthy controls. Methods. This case-control study compared a group of 30 patients with Behçet's disease with an age- and gender-matched control group of 30 healthy individuals. The buccal mucosal smears were stained using the Papanicolaou technique for cytomorphometric analyses. The nuclear and cytoplasmic areas were evaluated using digital image analysis; the ratio of nuclear to cytoplasmic areas and nuclear roundness are presented. Results. The nuclear and cytoplasmic areas of the BD patients' cells were significantly smaller than those of the healthy controls' cells, while the nucleus-to-cytoplasm ratio and neutrophil infiltration rate did not differ significantly between the groups. However, the nuclear area, cytoplasmic area, nucleus-to-cytoplasm ratio, and nuclear roundness factor were significantly higher in patients without aphthae. The neutrophil infiltration rate did not differ significantly in patients with or without aphthae. Conclusion. Behçet's disease can produce cytomorphometric changes in buccal cells that are detectable by exfoliative cytology and cytomorphometric analysis techniques. Hindawi Publishing Corporation 2016 2016-03-21 /pmc/articles/PMC4819084/ /pubmed/27088074 http://dx.doi.org/10.1155/2016/6035801 Text en Copyright © 2016 Erol Aktunc et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Aktunc, Erol Oz, Zehra Safi Bektas, Sibel Altinyazar, Cevdet Koca, Rafet Bostan, Serdar Cytomorphometric Characteristics of Buccal Mucosal Cells in Behçet's Disease Patients |
title | Cytomorphometric Characteristics of Buccal Mucosal Cells in Behçet's Disease Patients |
title_full | Cytomorphometric Characteristics of Buccal Mucosal Cells in Behçet's Disease Patients |
title_fullStr | Cytomorphometric Characteristics of Buccal Mucosal Cells in Behçet's Disease Patients |
title_full_unstemmed | Cytomorphometric Characteristics of Buccal Mucosal Cells in Behçet's Disease Patients |
title_short | Cytomorphometric Characteristics of Buccal Mucosal Cells in Behçet's Disease Patients |
title_sort | cytomorphometric characteristics of buccal mucosal cells in behçet's disease patients |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819084/ https://www.ncbi.nlm.nih.gov/pubmed/27088074 http://dx.doi.org/10.1155/2016/6035801 |
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