BitterX: a tool for understanding bitter taste in humans

BitterX is an open-access tool aimed at providing a platform for identifying human bitter taste receptors, TAS2Rs, for small molecules. It predicts TAS2Rs from the molecular structures of arbitrary chemicals by integrating two individual functionalities: bitterant verification and TAS2R recognition....

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Detalles Bibliográficos
Autores principales: Huang, Wenkang, Shen, Qiancheng, Su, Xubo, Ji, Mingfei, Liu, Xinyi, Chen, Yingyi, Lu, Shaoyong, Zhuang, Hanyi, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819188/
https://www.ncbi.nlm.nih.gov/pubmed/27040075
http://dx.doi.org/10.1038/srep23450
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author Huang, Wenkang
Shen, Qiancheng
Su, Xubo
Ji, Mingfei
Liu, Xinyi
Chen, Yingyi
Lu, Shaoyong
Zhuang, Hanyi
Zhang, Jian
author_facet Huang, Wenkang
Shen, Qiancheng
Su, Xubo
Ji, Mingfei
Liu, Xinyi
Chen, Yingyi
Lu, Shaoyong
Zhuang, Hanyi
Zhang, Jian
author_sort Huang, Wenkang
collection PubMed
description BitterX is an open-access tool aimed at providing a platform for identifying human bitter taste receptors, TAS2Rs, for small molecules. It predicts TAS2Rs from the molecular structures of arbitrary chemicals by integrating two individual functionalities: bitterant verification and TAS2R recognition. Using BitterX, several novel bitterants and their receptors were predicted and experimentally validated in the study. Therefore, BitterX may be an effective method for deciphering bitter taste coding and could be a useful tool for both basic bitter research in academia and new bitterant discoveries in the industry.
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spelling pubmed-48191882016-04-06 BitterX: a tool for understanding bitter taste in humans Huang, Wenkang Shen, Qiancheng Su, Xubo Ji, Mingfei Liu, Xinyi Chen, Yingyi Lu, Shaoyong Zhuang, Hanyi Zhang, Jian Sci Rep Article BitterX is an open-access tool aimed at providing a platform for identifying human bitter taste receptors, TAS2Rs, for small molecules. It predicts TAS2Rs from the molecular structures of arbitrary chemicals by integrating two individual functionalities: bitterant verification and TAS2R recognition. Using BitterX, several novel bitterants and their receptors were predicted and experimentally validated in the study. Therefore, BitterX may be an effective method for deciphering bitter taste coding and could be a useful tool for both basic bitter research in academia and new bitterant discoveries in the industry. Nature Publishing Group 2016-04-04 /pmc/articles/PMC4819188/ /pubmed/27040075 http://dx.doi.org/10.1038/srep23450 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Huang, Wenkang
Shen, Qiancheng
Su, Xubo
Ji, Mingfei
Liu, Xinyi
Chen, Yingyi
Lu, Shaoyong
Zhuang, Hanyi
Zhang, Jian
BitterX: a tool for understanding bitter taste in humans
title BitterX: a tool for understanding bitter taste in humans
title_full BitterX: a tool for understanding bitter taste in humans
title_fullStr BitterX: a tool for understanding bitter taste in humans
title_full_unstemmed BitterX: a tool for understanding bitter taste in humans
title_short BitterX: a tool for understanding bitter taste in humans
title_sort bitterx: a tool for understanding bitter taste in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819188/
https://www.ncbi.nlm.nih.gov/pubmed/27040075
http://dx.doi.org/10.1038/srep23450
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