Cargando…

A novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis

The attenuated degradation of articular cartilage by cartilage-specific deletion of fibroblast growth factor receptor 1 (FGFR1) in adult mice suggests that FGFR1 is a potential target for treating osteoarthritis (OA). The goal of the current study was to investigate the effect of a novel non-ATP-com...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Wei, Xie, Yangli, Wang, Quan, Wang, Xiaofeng, Luo, Fengtao, Zhou, Siru, Wang, Zuqiang, Huang, Junlan, Tan, Qiaoyan, Jin, Min, Qi, Huabing, Tang, Junzhou, Chen, Liang, Du, Xiaolan, Zhao, Chengguang, Liang, Guang, Chen, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819196/ https://www.ncbi.nlm.nih.gov/pubmed/27041213 http://dx.doi.org/10.1038/srep24042

Ejemplares similares

Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL‐1β/NF‐κB pathway
por: Wang, Zuqiang, et al.
Publicado: (2017)

Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice
por: Zhou, Siru, et al.
Publicado: (2016)

Long term usage of dexamethasone accelerating the initiation of osteoarthritis via enhancing the extracellular matrix calcification and apoptosis of chondrocytes
por: Chen, Liang, et al.
Publicado: (2021)

FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling
por: Zhou, Siru, et al.
Publicado: (2015)

Deformed Skull Morphology Is Caused by the Combined Effects of the Maldevelopment of Calvarias, Cranial Base and Brain in FGFR2-P253R Mice Mimicking Human Apert Syndrome
por: Luo, Fengtao, et al.
Publicado: (2017)

Low‐intensity pulsed ultrasound inhibits VEGFA expression in chondrocytes and protects against cartilage degeneration in experimental osteoarthritis
por: Guan, Mengtong, et al.
Publicado: (2020)

FGFR3 deficient mice have accelerated fracture repair
por: Xie, Yangli, et al.
Publicado: (2017)

Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice
por: Wang, Zuqiang, et al.
Publicado: (2022)

Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway
por: Zhang, Dali, et al.
Publicado: (2021)

Fibroblast Growth Factor Receptor 3 Deficiency Does Not Impair the Osteoanabolic Action of Parathyroid Hormone on Mice
por: Xie, Yangli, et al.
Publicado: (2016)

IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization
por: Fan, Mengtian, et al.
Publicado: (2022)

Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression
por: Fan, Aoyuan, et al.
Publicado: (2023)

Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration
por: Xu, Meng, et al.
Publicado: (2022)

A novel FGFR1-binding peptide exhibits anti-tumor effect on lung cancer by inhibiting proliferation and angiogenesis
por: Tan, Qiaoyan, et al.
Publicado: (2018)

The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1β production of macrophages and aggravated synovitis in osteoarthritis
por: Ni, Zhenhong, et al.
Publicado: (2019)

Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenuates Abnormal Calvarial Phenotypes in an Apert Syndrome Mouse Model
por: Luo, Fengtao, et al.
Publicado: (2018)

Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway
por: Sun, Xianding, et al.
Publicado: (2020)

Targeting Cartilage Degradation in Osteoarthritis
por: McClurg, Oliver, et al.
Publicado: (2021)

Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling
por: Sun, Xianding, et al.
Publicado: (2020)

Imbalanced development of anterior and posterior thorax is a causative factor triggering scoliosis
por: Chen, Bo, et al.
Publicado: (2019)

Gene expression and activity of cartilage degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblasts
por: Pásztói, Mária, et al.
Publicado: (2009)

Developmental Mechanisms in Articular Cartilage Degradation in Osteoarthritis
por: Tchetina, Elena V.
Publicado: (2011)

Tongbi Huoluo Decoction alleviates cartilage degeneration in knee osteoarthritis by inhibiting degradation of extracellular matrix
por: Chen, Weijian, et al.
Publicado: (2023)

Interleukin-29 Enhances Synovial Inflammation and Cartilage Degradation in Osteoarthritis
por: Xu, Lingxiao, et al.
Publicado: (2016)

IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis
por: Liang, Li, et al.
Publicado: (2023)

Exosomes: roles and therapeutic potential in osteoarthritis
por: Ni, Zhenhong, et al.
Publicado: (2020)

Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation
por: Zhuang, Chenyang, et al.
Publicado: (2021)

Effect of passive motion on articular cartilage in rat osteoarthritis
por: QIAN, JIE, et al.
Publicado: (2014)

Silibinin protects against osteoarthritis through inhibiting the inflammatory response and cartilage matrix degradation in vitro and in vivo
por: Zheng, Wenhao, et al.
Publicado: (2017)

[Retracted] Acetylsalicylic acid combined with diclofenac inhibits cartilage degradation in rabbit models of osteoarthritis
por: Liu, Jianqiang, et al.
Publicado: (2023)

Soluble biglycan: a potential mediator of cartilage degradation in osteoarthritis
por: Barreto, Goncalo, et al.
Publicado: (2015)

Models to define the stages of articular cartilage degradation in osteoarthritis development
por: Poulet, Blandine
Publicado: (2017)

FGF/FGFR signaling in health and disease
por: Xie, Yangli, et al.
Publicado: (2020)

Warm sparse-dense wave inhibits cartilage degradation in papain-induced osteoarthritis through the mitogen-activated protein kinase signaling pathway
por: Lin, Munan, et al.
Publicado: (2017)

Hypoxia-inducible factor expression is related to apoptosis and cartilage degradation in temporomandibular joint osteoarthritis
por: Zhang, Jun, et al.
Publicado: (2022)

Effect Of XBP1 Deficiency In Cartilage On The Regulatory Network Of LncRNA/circRNA-miRNA-mRNA
por: Li, Xiaoli, et al.
Publicado: (2022)

Melatonin Prevents Osteoarthritis-Induced Cartilage Degradation via Targeting MicroRNA-140
por: Zhang, Yijian, et al.
Publicado: (2019)

Natural Compounds: Potential Therapeutics for the Inhibition of Cartilage Matrix Degradation in Osteoarthritis
por: Ashruf, Omer S., et al.
Publicado: (2022)

In vitro model for the analysis of synovial fibroblast-mediated degradation of intact cartilage
por: Pretzel, David, et al.
Publicado: (2009)

XMU-MP-1 attenuates osteoarthritis via inhibiting cartilage degradation and chondrocyte apoptosis
por: Hao, Xue, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_nffkmhv0plaaim1i0pt7k0jcnv