Cargando…
Effect of Omega-3 Supplementation on Visfatin, Adiponectin, and Anthropometric Indices in Women with Polycystic Ovarian Syndrome
BACKGROUND: Polycystic ovary syndrome (PCOS) is a multifactorial, metabolic disorder. Characteristics are chronic anovulation, polycystic ovaries and hyperandrogenism. The aim of this study was to determine the effect of omega-3 supplementation on visfatin, adiponectin, and anthropometric indices in...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Avicenna Research Institute
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819211/ https://www.ncbi.nlm.nih.gov/pubmed/27110520 |
_version_ | 1782425161960521728 |
---|---|
author | Nadjarzadeh, Azadeh Dehghani-Firouzabadi, Razieh Daneshbodi, Hoorieh Lotfi, Mohammad Hassan Vaziri, Niloofar Mozaffari-Khosravi, Hassan |
author_facet | Nadjarzadeh, Azadeh Dehghani-Firouzabadi, Razieh Daneshbodi, Hoorieh Lotfi, Mohammad Hassan Vaziri, Niloofar Mozaffari-Khosravi, Hassan |
author_sort | Nadjarzadeh, Azadeh |
collection | PubMed |
description | BACKGROUND: Polycystic ovary syndrome (PCOS) is a multifactorial, metabolic disorder. Characteristics are chronic anovulation, polycystic ovaries and hyperandrogenism. The aim of this study was to determine the effect of omega-3 supplementation on visfatin, adiponectin, and anthropometric indices in PCOS women. METHODS: The study was a randomized double blind placebo-controlled clinical trial. It was conducted on 84 women with polycystic ovary syndrome (26.92±5.05 years, BMI=31.69 Kg/m(2)) who referred to the fertility and infertility research center and Shahid Sadoughi hospital in Yazd. After the examination, evaluation and para-medical assessment by obstetrician, they were recruited. They took 3 capsules of omega-3 (each one contained 180 mg EPA and 120 mg DHA) or placebo (each contained 1 g paraffin) daily for 8 weeks. Statistical analysis was paired T-test and student T-test, and a p<0.05 was considered statistically significant. RESULTS: After the intervention, visfatin concentration did not change in neither groups. But, at the end of the study, the mean of adiponectin concentration increased (p<0.001) in omega-3 group. Moreover, the mean of changes in this factor was significantly different between groups (p<0.005). FSH did not change in two groups of the study. However, the mean of LH decreased about 1.74 mlU/ml in omega-3 group (p<0.005). The mean of change of LH/FSH ratio between groups was significant (p<0.05). After the intervention, prolactin did not meaningfully change in both groups. CONCLUSION: Our results showed that 8 weeks of supplementation of omega-3 may have some beneficial effects on PCOS biochemical characteristics such as LH, LH/FSH, and adiponectin. |
format | Online Article Text |
id | pubmed-4819211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Avicenna Research Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-48192112016-04-22 Effect of Omega-3 Supplementation on Visfatin, Adiponectin, and Anthropometric Indices in Women with Polycystic Ovarian Syndrome Nadjarzadeh, Azadeh Dehghani-Firouzabadi, Razieh Daneshbodi, Hoorieh Lotfi, Mohammad Hassan Vaziri, Niloofar Mozaffari-Khosravi, Hassan J Reprod Infertil Original Article BACKGROUND: Polycystic ovary syndrome (PCOS) is a multifactorial, metabolic disorder. Characteristics are chronic anovulation, polycystic ovaries and hyperandrogenism. The aim of this study was to determine the effect of omega-3 supplementation on visfatin, adiponectin, and anthropometric indices in PCOS women. METHODS: The study was a randomized double blind placebo-controlled clinical trial. It was conducted on 84 women with polycystic ovary syndrome (26.92±5.05 years, BMI=31.69 Kg/m(2)) who referred to the fertility and infertility research center and Shahid Sadoughi hospital in Yazd. After the examination, evaluation and para-medical assessment by obstetrician, they were recruited. They took 3 capsules of omega-3 (each one contained 180 mg EPA and 120 mg DHA) or placebo (each contained 1 g paraffin) daily for 8 weeks. Statistical analysis was paired T-test and student T-test, and a p<0.05 was considered statistically significant. RESULTS: After the intervention, visfatin concentration did not change in neither groups. But, at the end of the study, the mean of adiponectin concentration increased (p<0.001) in omega-3 group. Moreover, the mean of changes in this factor was significantly different between groups (p<0.005). FSH did not change in two groups of the study. However, the mean of LH decreased about 1.74 mlU/ml in omega-3 group (p<0.005). The mean of change of LH/FSH ratio between groups was significant (p<0.05). After the intervention, prolactin did not meaningfully change in both groups. CONCLUSION: Our results showed that 8 weeks of supplementation of omega-3 may have some beneficial effects on PCOS biochemical characteristics such as LH, LH/FSH, and adiponectin. Avicenna Research Institute 2015 /pmc/articles/PMC4819211/ /pubmed/27110520 Text en Copyright© 2015, Avicenna Research Institute. This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Original Article Nadjarzadeh, Azadeh Dehghani-Firouzabadi, Razieh Daneshbodi, Hoorieh Lotfi, Mohammad Hassan Vaziri, Niloofar Mozaffari-Khosravi, Hassan Effect of Omega-3 Supplementation on Visfatin, Adiponectin, and Anthropometric Indices in Women with Polycystic Ovarian Syndrome |
title | Effect of Omega-3 Supplementation on Visfatin, Adiponectin, and Anthropometric Indices in Women with Polycystic Ovarian Syndrome |
title_full | Effect of Omega-3 Supplementation on Visfatin, Adiponectin, and Anthropometric Indices in Women with Polycystic Ovarian Syndrome |
title_fullStr | Effect of Omega-3 Supplementation on Visfatin, Adiponectin, and Anthropometric Indices in Women with Polycystic Ovarian Syndrome |
title_full_unstemmed | Effect of Omega-3 Supplementation on Visfatin, Adiponectin, and Anthropometric Indices in Women with Polycystic Ovarian Syndrome |
title_short | Effect of Omega-3 Supplementation on Visfatin, Adiponectin, and Anthropometric Indices in Women with Polycystic Ovarian Syndrome |
title_sort | effect of omega-3 supplementation on visfatin, adiponectin, and anthropometric indices in women with polycystic ovarian syndrome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819211/ https://www.ncbi.nlm.nih.gov/pubmed/27110520 |
work_keys_str_mv | AT nadjarzadehazadeh effectofomega3supplementationonvisfatinadiponectinandanthropometricindicesinwomenwithpolycysticovariansyndrome AT dehghanifirouzabadirazieh effectofomega3supplementationonvisfatinadiponectinandanthropometricindicesinwomenwithpolycysticovariansyndrome AT daneshbodihoorieh effectofomega3supplementationonvisfatinadiponectinandanthropometricindicesinwomenwithpolycysticovariansyndrome AT lotfimohammadhassan effectofomega3supplementationonvisfatinadiponectinandanthropometricindicesinwomenwithpolycysticovariansyndrome AT vaziriniloofar effectofomega3supplementationonvisfatinadiponectinandanthropometricindicesinwomenwithpolycysticovariansyndrome AT mozaffarikhosravihassan effectofomega3supplementationonvisfatinadiponectinandanthropometricindicesinwomenwithpolycysticovariansyndrome |