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Optical Magnetic Induction Tomography of the Heart
Atrial Fibrillation (AF) affects a significant fraction of the ageing population, causing a high level of morbidity and mortality. Despite its significance, the causes of AF are still not uniquely identified. This, combined with the lack of precise diagnostic and guiding tools, makes the clinical tr...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819224/ https://www.ncbi.nlm.nih.gov/pubmed/27040727 http://dx.doi.org/10.1038/srep23962 |
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author | Marmugi, Luca Renzoni, Ferruccio |
author_facet | Marmugi, Luca Renzoni, Ferruccio |
author_sort | Marmugi, Luca |
collection | PubMed |
description | Atrial Fibrillation (AF) affects a significant fraction of the ageing population, causing a high level of morbidity and mortality. Despite its significance, the causes of AF are still not uniquely identified. This, combined with the lack of precise diagnostic and guiding tools, makes the clinical treatment of AF sub-optimal. We identify magnetic induction tomography as the most promising technique for the investigation of the causes of fibrillation and for its clinical practice. We therefore propose a novel optical instrument based on optical atomic magnetometers, fulfilling the requirements for diagnostic mapping of the heart’s conductivity. The feasibility of the device is here discussed in view of the final application. Thanks to the potential of atomic magnetometers for miniaturisation and extreme sensitivity at room temperature, a new generation of compact and non-invasive diagnostic instrumentation, with both bedside and intra-operative operation capability, is envisioned. Possible scenarios both in clinical practice and biomedical research are then discussed. The flexibility of the system makes it promising also for application in other fields, such as neurology and oncology. |
format | Online Article Text |
id | pubmed-4819224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48192242016-04-06 Optical Magnetic Induction Tomography of the Heart Marmugi, Luca Renzoni, Ferruccio Sci Rep Article Atrial Fibrillation (AF) affects a significant fraction of the ageing population, causing a high level of morbidity and mortality. Despite its significance, the causes of AF are still not uniquely identified. This, combined with the lack of precise diagnostic and guiding tools, makes the clinical treatment of AF sub-optimal. We identify magnetic induction tomography as the most promising technique for the investigation of the causes of fibrillation and for its clinical practice. We therefore propose a novel optical instrument based on optical atomic magnetometers, fulfilling the requirements for diagnostic mapping of the heart’s conductivity. The feasibility of the device is here discussed in view of the final application. Thanks to the potential of atomic magnetometers for miniaturisation and extreme sensitivity at room temperature, a new generation of compact and non-invasive diagnostic instrumentation, with both bedside and intra-operative operation capability, is envisioned. Possible scenarios both in clinical practice and biomedical research are then discussed. The flexibility of the system makes it promising also for application in other fields, such as neurology and oncology. Nature Publishing Group 2016-04-04 /pmc/articles/PMC4819224/ /pubmed/27040727 http://dx.doi.org/10.1038/srep23962 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Marmugi, Luca Renzoni, Ferruccio Optical Magnetic Induction Tomography of the Heart |
title | Optical Magnetic Induction Tomography of the Heart |
title_full | Optical Magnetic Induction Tomography of the Heart |
title_fullStr | Optical Magnetic Induction Tomography of the Heart |
title_full_unstemmed | Optical Magnetic Induction Tomography of the Heart |
title_short | Optical Magnetic Induction Tomography of the Heart |
title_sort | optical magnetic induction tomography of the heart |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819224/ https://www.ncbi.nlm.nih.gov/pubmed/27040727 http://dx.doi.org/10.1038/srep23962 |
work_keys_str_mv | AT marmugiluca opticalmagneticinductiontomographyoftheheart AT renzoniferruccio opticalmagneticinductiontomographyoftheheart |