Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures

BACKGROUND: Myostatin (Mstn) is a negative regulator of muscle growth whose inhibition promotes muscle growth and regeneration. Dystrophin-deficient mdx mice in which myostatin is knocked out or inhibited postnatally have a less severe phenotype with greater total mass and strength and less fibrosis...

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Detalles Bibliográficos
Autores principales: Kornegay, Joe N., Bogan, Daniel J., Bogan, Janet R., Dow, Jennifer L., Wang, Jiahui, Fan, Zheng, Liu, Naili, Warsing, Leigh C., Grange, Robert W., Ahn, Mihye, Balog-Alvarez, Cynthia J., Cotten, Steven W., Willis, Monte S., Brinkmeyer-Langford, Candice, Zhu, Hongtu, Palandra, Joe, Morris, Carl A., Styner, Martin A., Wagner, Kathryn R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819282/
https://www.ncbi.nlm.nih.gov/pubmed/27047655
http://dx.doi.org/10.1186/s13395-016-0085-7

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