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Increased Local Spontaneous Neural Activity in the Left Precuneus Specific to Auditory Verbal Hallucinations of Schizophrenia

BACKGROUND: Auditory verbal hallucinations (AVHs) of schizophrenia have been associated with structural and functional alterations of some brain regions. However, the brain regional homogeneity (ReHo) alterations specific to AVHs of schizophrenia remain unclear. In the current study, we aimed to inv...

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Autores principales: Zhuo, Chuan-Jun, Zhu, Jia-Jia, Wang, Chun-Li, Wang, Li-Na, Li, Jie, Qin, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819301/
https://www.ncbi.nlm.nih.gov/pubmed/26996476
http://dx.doi.org/10.4103/0366-6999.178974
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author Zhuo, Chuan-Jun
Zhu, Jia-Jia
Wang, Chun-Li
Wang, Li-Na
Li, Jie
Qin, Wen
author_facet Zhuo, Chuan-Jun
Zhu, Jia-Jia
Wang, Chun-Li
Wang, Li-Na
Li, Jie
Qin, Wen
author_sort Zhuo, Chuan-Jun
collection PubMed
description BACKGROUND: Auditory verbal hallucinations (AVHs) of schizophrenia have been associated with structural and functional alterations of some brain regions. However, the brain regional homogeneity (ReHo) alterations specific to AVHs of schizophrenia remain unclear. In the current study, we aimed to investigate ReHo alterations specific to schizophrenic AVHs. METHODS: Thirty-five schizophrenic patients with AVH, 41 schizophrenic patients without AVHs, and fifty healthy subjects underwent resting-state functional magnetic resonance imaging. ReHo differences across the three groups were tested using a voxel-wise analysis. RESULTS: Compared with the healthy control group, the two schizophrenia groups showed significantly increased ReHo in the right caudate and inferior temporal gyrus and decreased ReHo in the bilateral postcentral gyrus and thalamus and the right inferior occipital gyrus (false discovery rate corrected, P < 0.05). More importantly, the AVH group exhibited significantly increased ReHo in the left precuneus compared with the non-AVH group. However, using correlation analysis, we did not find any correlation between the auditory hallucination rating scale score and the ReHo of brain regions. CONCLUSIONS: Our results suggest that increased ReHo in the left precuneus may be a pathological feature exclusive to schizophrenic AVHs.
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spelling pubmed-48193012016-04-05 Increased Local Spontaneous Neural Activity in the Left Precuneus Specific to Auditory Verbal Hallucinations of Schizophrenia Zhuo, Chuan-Jun Zhu, Jia-Jia Wang, Chun-Li Wang, Li-Na Li, Jie Qin, Wen Chin Med J (Engl) Original Article BACKGROUND: Auditory verbal hallucinations (AVHs) of schizophrenia have been associated with structural and functional alterations of some brain regions. However, the brain regional homogeneity (ReHo) alterations specific to AVHs of schizophrenia remain unclear. In the current study, we aimed to investigate ReHo alterations specific to schizophrenic AVHs. METHODS: Thirty-five schizophrenic patients with AVH, 41 schizophrenic patients without AVHs, and fifty healthy subjects underwent resting-state functional magnetic resonance imaging. ReHo differences across the three groups were tested using a voxel-wise analysis. RESULTS: Compared with the healthy control group, the two schizophrenia groups showed significantly increased ReHo in the right caudate and inferior temporal gyrus and decreased ReHo in the bilateral postcentral gyrus and thalamus and the right inferior occipital gyrus (false discovery rate corrected, P < 0.05). More importantly, the AVH group exhibited significantly increased ReHo in the left precuneus compared with the non-AVH group. However, using correlation analysis, we did not find any correlation between the auditory hallucination rating scale score and the ReHo of brain regions. CONCLUSIONS: Our results suggest that increased ReHo in the left precuneus may be a pathological feature exclusive to schizophrenic AVHs. Medknow Publications & Media Pvt Ltd 2016-04-05 /pmc/articles/PMC4819301/ /pubmed/26996476 http://dx.doi.org/10.4103/0366-6999.178974 Text en Copyright: © 2016 Chinese Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Zhuo, Chuan-Jun
Zhu, Jia-Jia
Wang, Chun-Li
Wang, Li-Na
Li, Jie
Qin, Wen
Increased Local Spontaneous Neural Activity in the Left Precuneus Specific to Auditory Verbal Hallucinations of Schizophrenia
title Increased Local Spontaneous Neural Activity in the Left Precuneus Specific to Auditory Verbal Hallucinations of Schizophrenia
title_full Increased Local Spontaneous Neural Activity in the Left Precuneus Specific to Auditory Verbal Hallucinations of Schizophrenia
title_fullStr Increased Local Spontaneous Neural Activity in the Left Precuneus Specific to Auditory Verbal Hallucinations of Schizophrenia
title_full_unstemmed Increased Local Spontaneous Neural Activity in the Left Precuneus Specific to Auditory Verbal Hallucinations of Schizophrenia
title_short Increased Local Spontaneous Neural Activity in the Left Precuneus Specific to Auditory Verbal Hallucinations of Schizophrenia
title_sort increased local spontaneous neural activity in the left precuneus specific to auditory verbal hallucinations of schizophrenia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819301/
https://www.ncbi.nlm.nih.gov/pubmed/26996476
http://dx.doi.org/10.4103/0366-6999.178974
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