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Single Nucleotide Polymorphism rs10919543 in FCGR2A/FCGR3A Region Confers Susceptibility to Takayasu Arteritis in Chinese Population

BACKGROUND: Takayasu arteritis (TA) is a rare inflammatory arteriopathy of unknown etiology. The aim of this study was to investigate the genetic susceptibility to TA in a Chinese population. METHODS: Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX...

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Detalles Bibliográficos
Autores principales: Qin, Fang, Wang, Hu, Song, Lei, Lu, Xi-Li, Yang, Li-Rui, Liang, Er-Peng, Wang, Wei, Zou, Yu-Bao, Bian, Jin, Wu, Hai-Ying, Zhou, Xian-Liang, Hui, Ru-Tai, Zhang, Hui-Min, Jiang, Xiong-Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819308/
https://www.ncbi.nlm.nih.gov/pubmed/26996483
http://dx.doi.org/10.4103/0366-6999.178965
Descripción
Sumario:BACKGROUND: Takayasu arteritis (TA) is a rare inflammatory arteriopathy of unknown etiology. The aim of this study was to investigate the genetic susceptibility to TA in a Chinese population. METHODS: Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rs10919543), and the HLA-B/MICA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014. A Chi-square test was used to test for genotype/allele frequencies variants. RESULTS: Among the four SNPs, rs10919543 was found to be significantly associated with TA in the studied population. The GG genotype of rs10919543 at the FCGR2A/FCGR3A locus is a high risk factor (odds ratio [OR] = 6.532, 95% confidence interval [CI] = 2.402 − 17.763, P < 0.001) for TA. Among TA patients, the level of eosinophil granulocytes (Eos) in the peripheral blood was observed to be higher in the GG group of rs10919543 (n = 23, Eos = 0.11 [0.08, 0.17] ×10(9)/L) than the GA + AA group (n = 100, Eos = 0.08 [0.05, 0.13] ×10(9)/L, P = 0.028). No correlation between the genotypes of the other three SNPs and TA patients was observed. CONCLUSIONS: Our findings revealed unique genetic pattern in Chinese TA patients that may be partly responsible for the higher risk of TA in this population. FCGR2A/FCGR3A-related immune disorder might contribute to the etiology of TA.