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Potent Human α-Amylase Inhibition by the β-Defensin-like Protein Helianthamide

[Image: see text] Selective inhibitors of human pancreatic α-amylase (HPA) are an effective means of controlling blood sugar levels in the management of diabetes. A high-throughput screen of marine natural product extracts led to the identification of a potent (K(i) = 10 pM) peptidic HPA inhibitor,...

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Detalles Bibliográficos
Autores principales:	Tysoe, Christina, Williams, Leslie K., Keyzers, Robert, Nguyen, Nham T., Tarling, Chris, Wicki, Jacqueline, Goddard-Borger, Ethan D., Aguda, Adeleke H., Perry, Suzanne, Foster, Leonard J., Andersen, Raymond J., Brayer, Gary D., Withers, Stephen G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819454/ https://www.ncbi.nlm.nih.gov/pubmed/27066537 http://dx.doi.org/10.1021/acscentsci.5b00399

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