The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis

Expression of the initiator methionine tRNA (tRNA(i)(Met)) is deregulated in cancer. Despite this fact, it is not currently known how tRNA(i)(Met) expression levels influence tumor progression. We have found that tRNA(i)(Met) expression is increased in carcinoma-associated fibroblasts, implicating d...

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Detalles Bibliográficos
Autores principales: Clarke, Cassie J., Berg, Tracy J., Birch, Joanna, Ennis, Darren, Mitchell, Louise, Cloix, Catherine, Campbell, Andrew, Sumpton, David, Nixon, Colin, Campbell, Kirsteen, Bridgeman, Victoria L., Vermeulen, Peter B., Foo, Shane, Kostaras, Eleftherios, Jones, J. Louise, Haywood, Linda, Pulleine, Ellie, Yin, Huabing, Strathdee, Douglas, Sansom, Owen, Blyth, Karen, McNeish, Iain, Zanivan, Sara, Reynolds, Andrew R., Norman, Jim C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819511/
https://www.ncbi.nlm.nih.gov/pubmed/26948875
http://dx.doi.org/10.1016/j.cub.2016.01.045

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