An investigation into aripiprazole’s partial D(2) agonist effects within the dorsolateral prefrontal cortex during working memory in healthy volunteers

RATIONALE: Working memory impairments in schizophrenia have been attributed to dysfunction of the dorsolateral prefrontal cortex (DLPFC) which in turn may be due to low DLPFC dopamine innervation. Conventional antipsychotic drugs block DLPFC D(2) receptors, and this may lead to further dysfunction a...

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Detalles Bibliográficos
Autores principales: Murphy, Anna, Dursun, Serdar, McKie, Shane, Elliott, Rebecca, Deakin, John Francis William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819596/
https://www.ncbi.nlm.nih.gov/pubmed/26900078
http://dx.doi.org/10.1007/s00213-016-4234-9

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