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Mitochondrial DNA Depletion in Respiratory Chain–Deficient Parkinson Disease Neurons

OBJECTIVE: To determine the extent of respiratory chain abnormalities and investigate the contribution of mtDNA to the loss of respiratory chain complexes (CI–IV) in the substantia nigra (SN) of idiopathic Parkinson disease (IPD) patients at the single‐neuron level. METHODS: Multiple‐label immunoflu...

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Detalles Bibliográficos
Autores principales:	Grünewald, Anne, Rygiel, Karolina A., Hepplewhite, Philippa D., Morris, Christopher M., Picard, Martin, Turnbull, Doug M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819690/ https://www.ncbi.nlm.nih.gov/pubmed/26605748 http://dx.doi.org/10.1002/ana.24571

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