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Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions

Niemann‐pick type C1 (NPC1) is an endo/lysosomal membrane protein involved in intracellular cholesterol trafficking, and its luminal domain C is an essential endosomal receptor for Ebola and Marburg viruses. We have determined the crystal structure of glycosylated NPC1 luminal domain C and find all...

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Detalles Bibliográficos
Autores principales:	Zhao, Yuguang, Ren, Jingshan, Harlos, Karl, Stuart, David I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Research Letters
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819692/ https://www.ncbi.nlm.nih.gov/pubmed/26846330 http://dx.doi.org/10.1002/1873-3468.12089

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