The potential role of regulator of G‐protein signaling 16 in cell motility mediated by δEF1 family proteins

The epithelial–mesenchymal transition (EMT) is associated with tumor progression. We reported previously that expression of the δEF1 family proteins (δEF1/ZEB1 and SIP1/ZEB2), key regulators of the EMT, is positively correlated with EMT phenotypes and aggressiveness of breast cancer. Here, we show t...

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Detalles Bibliográficos
Autores principales: Hoshi, Yuta, Endo, Kaori, Shirakihara, Takuya, Fukagawa, Akihiko, Miyazawa, Keiji, Saitoh, Masao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819697/
https://www.ncbi.nlm.nih.gov/pubmed/26823172
http://dx.doi.org/10.1002/1873-3468.12042
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author Hoshi, Yuta
Endo, Kaori
Shirakihara, Takuya
Fukagawa, Akihiko
Miyazawa, Keiji
Saitoh, Masao
author_facet Hoshi, Yuta
Endo, Kaori
Shirakihara, Takuya
Fukagawa, Akihiko
Miyazawa, Keiji
Saitoh, Masao
author_sort Hoshi, Yuta
collection PubMed
description The epithelial–mesenchymal transition (EMT) is associated with tumor progression. We reported previously that expression of the δEF1 family proteins (δEF1/ZEB1 and SIP1/ZEB2), key regulators of the EMT, is positively correlated with EMT phenotypes and aggressiveness of breast cancer. Here, we show that the expression levels of regulator of G‐protein signaling 16 (RGS16) are negatively correlated with those of the δEF1 family proteins. On the basis of the results of gain‐ and loss‐of‐function analyses, we suggest that δEF1 family proteins promote cell motility of breast cancer cells directly or indirectly through repressing expression of RGS16.
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spelling pubmed-48196972016-04-28 The potential role of regulator of G‐protein signaling 16 in cell motility mediated by δEF1 family proteins Hoshi, Yuta Endo, Kaori Shirakihara, Takuya Fukagawa, Akihiko Miyazawa, Keiji Saitoh, Masao FEBS Lett Research Letters The epithelial–mesenchymal transition (EMT) is associated with tumor progression. We reported previously that expression of the δEF1 family proteins (δEF1/ZEB1 and SIP1/ZEB2), key regulators of the EMT, is positively correlated with EMT phenotypes and aggressiveness of breast cancer. Here, we show that the expression levels of regulator of G‐protein signaling 16 (RGS16) are negatively correlated with those of the δEF1 family proteins. On the basis of the results of gain‐ and loss‐of‐function analyses, we suggest that δEF1 family proteins promote cell motility of breast cancer cells directly or indirectly through repressing expression of RGS16. John Wiley and Sons Inc. 2016-01-27 2016-01 /pmc/articles/PMC4819697/ /pubmed/26823172 http://dx.doi.org/10.1002/1873-3468.12042 Text en © 2015 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Letters
Hoshi, Yuta
Endo, Kaori
Shirakihara, Takuya
Fukagawa, Akihiko
Miyazawa, Keiji
Saitoh, Masao
The potential role of regulator of G‐protein signaling 16 in cell motility mediated by δEF1 family proteins
title The potential role of regulator of G‐protein signaling 16 in cell motility mediated by δEF1 family proteins
title_full The potential role of regulator of G‐protein signaling 16 in cell motility mediated by δEF1 family proteins
title_fullStr The potential role of regulator of G‐protein signaling 16 in cell motility mediated by δEF1 family proteins
title_full_unstemmed The potential role of regulator of G‐protein signaling 16 in cell motility mediated by δEF1 family proteins
title_short The potential role of regulator of G‐protein signaling 16 in cell motility mediated by δEF1 family proteins
title_sort potential role of regulator of g‐protein signaling 16 in cell motility mediated by δef1 family proteins
topic Research Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819697/
https://www.ncbi.nlm.nih.gov/pubmed/26823172
http://dx.doi.org/10.1002/1873-3468.12042
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