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Light-triggered chemical amplification to accelerate degradation and release from polymeric particles

We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer bac...

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Detalles Bibliográficos
Autores principales: Olejniczak, Jason, Nguyen Huu, Viet Anh, Lux, Jacques, Grossman, Madeleine, He, Sha, Almutairi, Adah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819761/
https://www.ncbi.nlm.nih.gov/pubmed/26445896
http://dx.doi.org/10.1039/c5cc06143a
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author Olejniczak, Jason
Nguyen Huu, Viet Anh
Lux, Jacques
Grossman, Madeleine
He, Sha
Almutairi, Adah
author_facet Olejniczak, Jason
Nguyen Huu, Viet Anh
Lux, Jacques
Grossman, Madeleine
He, Sha
Almutairi, Adah
author_sort Olejniczak, Jason
collection PubMed
description We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH.
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spelling pubmed-48197612016-04-22 Light-triggered chemical amplification to accelerate degradation and release from polymeric particles Olejniczak, Jason Nguyen Huu, Viet Anh Lux, Jacques Grossman, Madeleine He, Sha Almutairi, Adah Chem Commun (Camb) Chemistry We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH. Royal Society of Chemistry 2015-12-11 2015-10-08 /pmc/articles/PMC4819761/ /pubmed/26445896 http://dx.doi.org/10.1039/c5cc06143a Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Olejniczak, Jason
Nguyen Huu, Viet Anh
Lux, Jacques
Grossman, Madeleine
He, Sha
Almutairi, Adah
Light-triggered chemical amplification to accelerate degradation and release from polymeric particles
title Light-triggered chemical amplification to accelerate degradation and release from polymeric particles
title_full Light-triggered chemical amplification to accelerate degradation and release from polymeric particles
title_fullStr Light-triggered chemical amplification to accelerate degradation and release from polymeric particles
title_full_unstemmed Light-triggered chemical amplification to accelerate degradation and release from polymeric particles
title_short Light-triggered chemical amplification to accelerate degradation and release from polymeric particles
title_sort light-triggered chemical amplification to accelerate degradation and release from polymeric particles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819761/
https://www.ncbi.nlm.nih.gov/pubmed/26445896
http://dx.doi.org/10.1039/c5cc06143a
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