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Light-triggered chemical amplification to accelerate degradation and release from polymeric particles
We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer bac...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819761/ https://www.ncbi.nlm.nih.gov/pubmed/26445896 http://dx.doi.org/10.1039/c5cc06143a |
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author | Olejniczak, Jason Nguyen Huu, Viet Anh Lux, Jacques Grossman, Madeleine He, Sha Almutairi, Adah |
author_facet | Olejniczak, Jason Nguyen Huu, Viet Anh Lux, Jacques Grossman, Madeleine He, Sha Almutairi, Adah |
author_sort | Olejniczak, Jason |
collection | PubMed |
description | We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH. |
format | Online Article Text |
id | pubmed-4819761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-48197612016-04-22 Light-triggered chemical amplification to accelerate degradation and release from polymeric particles Olejniczak, Jason Nguyen Huu, Viet Anh Lux, Jacques Grossman, Madeleine He, Sha Almutairi, Adah Chem Commun (Camb) Chemistry We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH. Royal Society of Chemistry 2015-12-11 2015-10-08 /pmc/articles/PMC4819761/ /pubmed/26445896 http://dx.doi.org/10.1039/c5cc06143a Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Chemistry Olejniczak, Jason Nguyen Huu, Viet Anh Lux, Jacques Grossman, Madeleine He, Sha Almutairi, Adah Light-triggered chemical amplification to accelerate degradation and release from polymeric particles |
title | Light-triggered chemical amplification to accelerate degradation and release from polymeric particles
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title_full | Light-triggered chemical amplification to accelerate degradation and release from polymeric particles
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title_fullStr | Light-triggered chemical amplification to accelerate degradation and release from polymeric particles
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title_full_unstemmed | Light-triggered chemical amplification to accelerate degradation and release from polymeric particles
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title_short | Light-triggered chemical amplification to accelerate degradation and release from polymeric particles
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title_sort | light-triggered chemical amplification to accelerate degradation and release from polymeric particles |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819761/ https://www.ncbi.nlm.nih.gov/pubmed/26445896 http://dx.doi.org/10.1039/c5cc06143a |
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