The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases

Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic molecules in circulation. LCN2 has been recently characterized as an adipose-derived cytokine. This adipokine is believed to bin...

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Autores principales: Abella, Vanessa, Scotece, Morena, Conde, Javier, Gómez, Rodolfo, Lois, Ana, Pino, Jesús, Gómez-Reino, Juan J., Lago, Francisca, Mobasheri, Ali, Gualillo, Oreste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819811/
https://www.ncbi.nlm.nih.gov/pubmed/26671823
http://dx.doi.org/10.3109/1354750X.2015.1123354
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author Abella, Vanessa
Scotece, Morena
Conde, Javier
Gómez, Rodolfo
Lois, Ana
Pino, Jesús
Gómez-Reino, Juan J.
Lago, Francisca
Mobasheri, Ali
Gualillo, Oreste
author_facet Abella, Vanessa
Scotece, Morena
Conde, Javier
Gómez, Rodolfo
Lois, Ana
Pino, Jesús
Gómez-Reino, Juan J.
Lago, Francisca
Mobasheri, Ali
Gualillo, Oreste
author_sort Abella, Vanessa
collection PubMed
description Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic molecules in circulation. LCN2 has been recently characterized as an adipose-derived cytokine. This adipokine is believed to bind small substances, such as steroids and lipopolysaccharides, and has been reported to have roles in the induction of apoptosis in hematopoietic cells, transport of fatty acids and iron, modulation of inflammation, and metabolic homeostasis. Recently, LCN2 has emerged as a useful biomarker and rheumatic diseases. This review provides an overview of LCN2 in inflammation, immunity, and metabolism.
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spelling pubmed-48198112016-04-22 The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases Abella, Vanessa Scotece, Morena Conde, Javier Gómez, Rodolfo Lois, Ana Pino, Jesús Gómez-Reino, Juan J. Lago, Francisca Mobasheri, Ali Gualillo, Oreste Biomarkers Research Article Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic molecules in circulation. LCN2 has been recently characterized as an adipose-derived cytokine. This adipokine is believed to bind small substances, such as steroids and lipopolysaccharides, and has been reported to have roles in the induction of apoptosis in hematopoietic cells, transport of fatty acids and iron, modulation of inflammation, and metabolic homeostasis. Recently, LCN2 has emerged as a useful biomarker and rheumatic diseases. This review provides an overview of LCN2 in inflammation, immunity, and metabolism. Taylor & Francis 2015-11-17 2015-12-15 /pmc/articles/PMC4819811/ /pubmed/26671823 http://dx.doi.org/10.3109/1354750X.2015.1123354 Text en © 2015 The Author(s). Published by Taylor & Francis. http://creativecommons.org/Licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/Licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, orbuilt upon in any way.
spellingShingle Research Article
Abella, Vanessa
Scotece, Morena
Conde, Javier
Gómez, Rodolfo
Lois, Ana
Pino, Jesús
Gómez-Reino, Juan J.
Lago, Francisca
Mobasheri, Ali
Gualillo, Oreste
The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases
title The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases
title_full The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases
title_fullStr The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases
title_full_unstemmed The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases
title_short The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases
title_sort potential of lipocalin-2/ngal as biomarker for inflammatory and metabolic diseases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819811/
https://www.ncbi.nlm.nih.gov/pubmed/26671823
http://dx.doi.org/10.3109/1354750X.2015.1123354
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