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Personality traits and the risk for Parkinson disease: a prospective study

In this study, we explored the association between the personality traits, neuroticism and introversion, and risk of Parkinson disease (PD). A population-based cohort study was conducted using questionnaire data from the Swedish Twin Registry for twins born 1926–1958 (n > 29,000). Personality tra...

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Autores principales: Sieurin, Johanna, Gustavsson, Petter, Weibull, Caroline Elise, Feldman, Adina Leiah, Petzinger, Giselle Maria, Gatz, Margaret, Pedersen, Nancy Lee, Wirdefeldt, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819915/
https://www.ncbi.nlm.nih.gov/pubmed/26130127
http://dx.doi.org/10.1007/s10654-015-0062-1
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author Sieurin, Johanna
Gustavsson, Petter
Weibull, Caroline Elise
Feldman, Adina Leiah
Petzinger, Giselle Maria
Gatz, Margaret
Pedersen, Nancy Lee
Wirdefeldt, Karin
author_facet Sieurin, Johanna
Gustavsson, Petter
Weibull, Caroline Elise
Feldman, Adina Leiah
Petzinger, Giselle Maria
Gatz, Margaret
Pedersen, Nancy Lee
Wirdefeldt, Karin
author_sort Sieurin, Johanna
collection PubMed
description In this study, we explored the association between the personality traits, neuroticism and introversion, and risk of Parkinson disease (PD). A population-based cohort study was conducted using questionnaire data from the Swedish Twin Registry for twins born 1926–1958 (n > 29,000). Personality traits were assessed in 1973 by a short form of Eysenck’s Personality Inventory. The cohort was followed from 1974 to 2012 through Swedish patient and cause of death registers for PD ascertainment. Cox proportional hazards regression was used to estimate subsequent risk of PD, adjusting for attained age, sex and smoking. A mediation analysis was performed to further explore the role of smoking in the relationship between personality trait and PD. Confounding by familial factors was explored using a within-pair analysis. During a mean follow-up time of 36.8 years, 197 incident PD cases were identified. Both neuroticism and introversion were associated with an increased risk of PD after adjustment. Smoking was a significant mediator in the relationship between personality traits and PD that partly accounted for the effect of introversion, whereas it acted as a suppressor for the effect of neuroticism on PD risk. In the within-pair analyses, associations for neuroticism and introversion were attenuated. In conclusion, our study provides evidence that neuroticism is associated with an increased risk of PD that is in part suppressed by smoking. There was a weak association between introversion and PD and this effect was at least partly mediated through smoking. The observed effects may partly be explained by familial factors shared by twins.
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spelling pubmed-48199152016-04-11 Personality traits and the risk for Parkinson disease: a prospective study Sieurin, Johanna Gustavsson, Petter Weibull, Caroline Elise Feldman, Adina Leiah Petzinger, Giselle Maria Gatz, Margaret Pedersen, Nancy Lee Wirdefeldt, Karin Eur J Epidemiol Psychiatric Epidemiology In this study, we explored the association between the personality traits, neuroticism and introversion, and risk of Parkinson disease (PD). A population-based cohort study was conducted using questionnaire data from the Swedish Twin Registry for twins born 1926–1958 (n > 29,000). Personality traits were assessed in 1973 by a short form of Eysenck’s Personality Inventory. The cohort was followed from 1974 to 2012 through Swedish patient and cause of death registers for PD ascertainment. Cox proportional hazards regression was used to estimate subsequent risk of PD, adjusting for attained age, sex and smoking. A mediation analysis was performed to further explore the role of smoking in the relationship between personality trait and PD. Confounding by familial factors was explored using a within-pair analysis. During a mean follow-up time of 36.8 years, 197 incident PD cases were identified. Both neuroticism and introversion were associated with an increased risk of PD after adjustment. Smoking was a significant mediator in the relationship between personality traits and PD that partly accounted for the effect of introversion, whereas it acted as a suppressor for the effect of neuroticism on PD risk. In the within-pair analyses, associations for neuroticism and introversion were attenuated. In conclusion, our study provides evidence that neuroticism is associated with an increased risk of PD that is in part suppressed by smoking. There was a weak association between introversion and PD and this effect was at least partly mediated through smoking. The observed effects may partly be explained by familial factors shared by twins. Springer Netherlands 2015-07-01 2016 /pmc/articles/PMC4819915/ /pubmed/26130127 http://dx.doi.org/10.1007/s10654-015-0062-1 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Psychiatric Epidemiology
Sieurin, Johanna
Gustavsson, Petter
Weibull, Caroline Elise
Feldman, Adina Leiah
Petzinger, Giselle Maria
Gatz, Margaret
Pedersen, Nancy Lee
Wirdefeldt, Karin
Personality traits and the risk for Parkinson disease: a prospective study
title Personality traits and the risk for Parkinson disease: a prospective study
title_full Personality traits and the risk for Parkinson disease: a prospective study
title_fullStr Personality traits and the risk for Parkinson disease: a prospective study
title_full_unstemmed Personality traits and the risk for Parkinson disease: a prospective study
title_short Personality traits and the risk for Parkinson disease: a prospective study
title_sort personality traits and the risk for parkinson disease: a prospective study
topic Psychiatric Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819915/
https://www.ncbi.nlm.nih.gov/pubmed/26130127
http://dx.doi.org/10.1007/s10654-015-0062-1
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