Maintaining memory of silencing at imprinted differentially methylated regions

Imprinted genes are an exceptional cluster of genes which are expressed in a parent-of-origin dependent fashion. This allele-specific expression is dependent on differential DNA methylation which is established in the parental germlines in a sex-specific manner. The DNA methylation imprint is accomp...

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Detalles Bibliográficos
Autores principales: Voon, Hsiao P. J., Gibbons, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819931/
https://www.ncbi.nlm.nih.gov/pubmed/26883803
http://dx.doi.org/10.1007/s00018-016-2157-6
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author Voon, Hsiao P. J.
Gibbons, Richard J.
author_facet Voon, Hsiao P. J.
Gibbons, Richard J.
author_sort Voon, Hsiao P. J.
collection PubMed
description Imprinted genes are an exceptional cluster of genes which are expressed in a parent-of-origin dependent fashion. This allele-specific expression is dependent on differential DNA methylation which is established in the parental germlines in a sex-specific manner. The DNA methylation imprint is accompanied by heterochromatin modifications which must be continuously maintained through development. This review summarises the factors which are important for protecting the epigenetic modifications at imprinted differentially methylated regions (DMRs), including PGC7, ZFP57 and the ATRX/Daxx/H3.3 complex. We discuss how these factors maintain heterochromatin silencing, not only at imprinted DMRs, but also other heterochromatic regions in the genome.
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spelling pubmed-48199312016-04-11 Maintaining memory of silencing at imprinted differentially methylated regions Voon, Hsiao P. J. Gibbons, Richard J. Cell Mol Life Sci Review Imprinted genes are an exceptional cluster of genes which are expressed in a parent-of-origin dependent fashion. This allele-specific expression is dependent on differential DNA methylation which is established in the parental germlines in a sex-specific manner. The DNA methylation imprint is accompanied by heterochromatin modifications which must be continuously maintained through development. This review summarises the factors which are important for protecting the epigenetic modifications at imprinted differentially methylated regions (DMRs), including PGC7, ZFP57 and the ATRX/Daxx/H3.3 complex. We discuss how these factors maintain heterochromatin silencing, not only at imprinted DMRs, but also other heterochromatic regions in the genome. Springer International Publishing 2016-02-16 2016 /pmc/articles/PMC4819931/ /pubmed/26883803 http://dx.doi.org/10.1007/s00018-016-2157-6 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Voon, Hsiao P. J.
Gibbons, Richard J.
Maintaining memory of silencing at imprinted differentially methylated regions
title Maintaining memory of silencing at imprinted differentially methylated regions
title_full Maintaining memory of silencing at imprinted differentially methylated regions
title_fullStr Maintaining memory of silencing at imprinted differentially methylated regions
title_full_unstemmed Maintaining memory of silencing at imprinted differentially methylated regions
title_short Maintaining memory of silencing at imprinted differentially methylated regions
title_sort maintaining memory of silencing at imprinted differentially methylated regions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819931/
https://www.ncbi.nlm.nih.gov/pubmed/26883803
http://dx.doi.org/10.1007/s00018-016-2157-6
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