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Magnetic Propulsion of Microswimmers with DNA-Based Flagellar Bundles

[Image: see text] We show that DNA-based self-assembly can serve as a general and flexible tool to construct artificial flagella of several micrometers in length and only tens of nanometers in diameter. By attaching the DNA flagella to biocompatible magnetic microparticles, we provide a proof of con...

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Autores principales: Maier, Alexander M., Weig, Cornelius, Oswald, Peter, Frey, Erwin, Fischer, Peer, Liedl, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819949/
https://www.ncbi.nlm.nih.gov/pubmed/26821214
http://dx.doi.org/10.1021/acs.nanolett.5b03716
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author Maier, Alexander M.
Weig, Cornelius
Oswald, Peter
Frey, Erwin
Fischer, Peer
Liedl, Tim
author_facet Maier, Alexander M.
Weig, Cornelius
Oswald, Peter
Frey, Erwin
Fischer, Peer
Liedl, Tim
author_sort Maier, Alexander M.
collection PubMed
description [Image: see text] We show that DNA-based self-assembly can serve as a general and flexible tool to construct artificial flagella of several micrometers in length and only tens of nanometers in diameter. By attaching the DNA flagella to biocompatible magnetic microparticles, we provide a proof of concept demonstration of hybrid structures that, when rotated in an external magnetic field, propel by means of a flagellar bundle, similar to self-propelling peritrichous bacteria. Our theoretical analysis predicts that flagellar bundles that possess a length-dependent bending stiffness should exhibit a superior swimming speed compared to swimmers with a single appendage. The DNA self-assembly method permits the realization of these improved flagellar bundles in good agreement with our quantitative model. DNA flagella with well-controlled shape could fundamentally increase the functionality of fully biocompatible nanorobots and extend the scope and complexity of active materials.
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spelling pubmed-48199492016-04-06 Magnetic Propulsion of Microswimmers with DNA-Based Flagellar Bundles Maier, Alexander M. Weig, Cornelius Oswald, Peter Frey, Erwin Fischer, Peer Liedl, Tim Nano Lett [Image: see text] We show that DNA-based self-assembly can serve as a general and flexible tool to construct artificial flagella of several micrometers in length and only tens of nanometers in diameter. By attaching the DNA flagella to biocompatible magnetic microparticles, we provide a proof of concept demonstration of hybrid structures that, when rotated in an external magnetic field, propel by means of a flagellar bundle, similar to self-propelling peritrichous bacteria. Our theoretical analysis predicts that flagellar bundles that possess a length-dependent bending stiffness should exhibit a superior swimming speed compared to swimmers with a single appendage. The DNA self-assembly method permits the realization of these improved flagellar bundles in good agreement with our quantitative model. DNA flagella with well-controlled shape could fundamentally increase the functionality of fully biocompatible nanorobots and extend the scope and complexity of active materials. American Chemical Society 2016-01-28 2016-02-10 /pmc/articles/PMC4819949/ /pubmed/26821214 http://dx.doi.org/10.1021/acs.nanolett.5b03716 Text en Copyright © 2016 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Maier, Alexander M.
Weig, Cornelius
Oswald, Peter
Frey, Erwin
Fischer, Peer
Liedl, Tim
Magnetic Propulsion of Microswimmers with DNA-Based Flagellar Bundles
title Magnetic Propulsion of Microswimmers with DNA-Based Flagellar Bundles
title_full Magnetic Propulsion of Microswimmers with DNA-Based Flagellar Bundles
title_fullStr Magnetic Propulsion of Microswimmers with DNA-Based Flagellar Bundles
title_full_unstemmed Magnetic Propulsion of Microswimmers with DNA-Based Flagellar Bundles
title_short Magnetic Propulsion of Microswimmers with DNA-Based Flagellar Bundles
title_sort magnetic propulsion of microswimmers with dna-based flagellar bundles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819949/
https://www.ncbi.nlm.nih.gov/pubmed/26821214
http://dx.doi.org/10.1021/acs.nanolett.5b03716
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