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Structure-Based Analysis Reveals Cancer Missense Mutations Target Protein Interaction Interfaces
Recently it has been shown that cancer mutations selectively target protein-protein interactions. We hypothesized that mutations affecting distinct protein interactions involving established cancer genes could contribute to tumor heterogeneity, and that novel mechanistic insights might be gained int...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820104/ https://www.ncbi.nlm.nih.gov/pubmed/27043210 http://dx.doi.org/10.1371/journal.pone.0152929 |