Beneficial Effects of Anti-Interleukin-6 Antibodies on Impaired Gastrointestinal Motility, Inflammation and Increased Colonic Permeability in a Murine Model of Sepsis Are Most Pronounced When Administered in a Preventive Setup

BACKGROUND AND OBJECTIVES: During sepsis, gastrointestinal ileus, mucosal barrier dysfunction and bacterial translocation are accepted to be important triggers that can maintain or exacerbate the septic state. In the caecal ligation and puncture animal model of sepsis, we demonstrated that systemic...

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Detalles Bibliográficos
Autores principales: Nullens, Sara, Staessens, Michael, Peleman, Cédric, Plaeke, Philip, Malhotra-Kumar, Surbhi, Francque, Sven, De Man, Joris G., De Winter, Benedicte Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820138/
https://www.ncbi.nlm.nih.gov/pubmed/27044016
http://dx.doi.org/10.1371/journal.pone.0152914

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