Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1

Eutypenoids A–C (1–3), pimarane diterpenoid alkaloid and two ring A rearranged pimarane diterpenoids, were isolated from the culture of Eutypella sp. D-1 obtained from high-latitude soil of the Arctic. Their structures, including absolute configurations, were authenticated on the basis of the mass s...

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Autores principales: Zhang, Liu-Qiang, Chen, Xiao-Chong, Chen, Zhao-Qiang, Wang, Gui-Min, Zhu, Shi-Guo, Yang, Yi-Fu, Chen, Kai-Xian, Liu, Xiao-Yu, Li, Yi-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820298/
https://www.ncbi.nlm.nih.gov/pubmed/26959036
http://dx.doi.org/10.3390/md14030044
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author Zhang, Liu-Qiang
Chen, Xiao-Chong
Chen, Zhao-Qiang
Wang, Gui-Min
Zhu, Shi-Guo
Yang, Yi-Fu
Chen, Kai-Xian
Liu, Xiao-Yu
Li, Yi-Ming
author_facet Zhang, Liu-Qiang
Chen, Xiao-Chong
Chen, Zhao-Qiang
Wang, Gui-Min
Zhu, Shi-Guo
Yang, Yi-Fu
Chen, Kai-Xian
Liu, Xiao-Yu
Li, Yi-Ming
author_sort Zhang, Liu-Qiang
collection PubMed
description Eutypenoids A–C (1–3), pimarane diterpenoid alkaloid and two ring A rearranged pimarane diterpenoids, were isolated from the culture of Eutypella sp. D-1 obtained from high-latitude soil of the Arctic. Their structures, including absolute configurations, were authenticated on the basis of the mass spectroscopy (MS), nuclear magnetic resonance (NMR), X-ray crystallography, and electronic circular dichroism (ECD) analysis. The immunosuppressive effects of eutypenoids A–C (1–3) were studied using a ConA-induced splenocyte proliferation model, which suggested that 2 exhibited potent immunosuppressive activities.
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spelling pubmed-48202982016-04-04 Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1 Zhang, Liu-Qiang Chen, Xiao-Chong Chen, Zhao-Qiang Wang, Gui-Min Zhu, Shi-Guo Yang, Yi-Fu Chen, Kai-Xian Liu, Xiao-Yu Li, Yi-Ming Mar Drugs Article Eutypenoids A–C (1–3), pimarane diterpenoid alkaloid and two ring A rearranged pimarane diterpenoids, were isolated from the culture of Eutypella sp. D-1 obtained from high-latitude soil of the Arctic. Their structures, including absolute configurations, were authenticated on the basis of the mass spectroscopy (MS), nuclear magnetic resonance (NMR), X-ray crystallography, and electronic circular dichroism (ECD) analysis. The immunosuppressive effects of eutypenoids A–C (1–3) were studied using a ConA-induced splenocyte proliferation model, which suggested that 2 exhibited potent immunosuppressive activities. MDPI 2016-03-07 /pmc/articles/PMC4820298/ /pubmed/26959036 http://dx.doi.org/10.3390/md14030044 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Liu-Qiang
Chen, Xiao-Chong
Chen, Zhao-Qiang
Wang, Gui-Min
Zhu, Shi-Guo
Yang, Yi-Fu
Chen, Kai-Xian
Liu, Xiao-Yu
Li, Yi-Ming
Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1
title Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1
title_full Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1
title_fullStr Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1
title_full_unstemmed Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1
title_short Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1
title_sort eutypenoids a–c: novel pimarane diterpenoids from the arctic fungus eutypella sp. d-1
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820298/
https://www.ncbi.nlm.nih.gov/pubmed/26959036
http://dx.doi.org/10.3390/md14030044
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