Regulation of protein-ligand binding affinity by hydrogen bond pairing

Hydrogen (H)-bonds potentiate diverse cellular functions by facilitating molecular interactions. The mechanism and the extent to which H-bonds regulate molecular interactions are a largely unresolved problem in biology because the H-bonding process continuously competes with bulk water. This interfe...

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Detalles Bibliográficos
Autores principales: Chen, Deliang, Oezguen, Numan, Urvil, Petri, Ferguson, Colin, Dann, Sara M., Savidge, Tor C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820369/
https://www.ncbi.nlm.nih.gov/pubmed/27051863
http://dx.doi.org/10.1126/sciadv.1501240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820369/
https://www.ncbi.nlm.nih.gov/pubmed/27051863
http://dx.doi.org/10.1126/sciadv.1501240

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