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Regulation of protein-ligand binding affinity by hydrogen bond pairing

Hydrogen (H)-bonds potentiate diverse cellular functions by facilitating molecular interactions. The mechanism and the extent to which H-bonds regulate molecular interactions are a largely unresolved problem in biology because the H-bonding process continuously competes with bulk water. This interfe...

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Detalles Bibliográficos
Autores principales:	Chen, Deliang, Oezguen, Numan, Urvil, Petri, Ferguson, Colin, Dann, Sara M., Savidge, Tor C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820369/ https://www.ncbi.nlm.nih.gov/pubmed/27051863 http://dx.doi.org/10.1126/sciadv.1501240

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