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Ancient mitochondrial DNA provides high-resolution time scale of the peopling of the Americas
The exact timing, route, and process of the initial peopling of the Americas remains uncertain despite much research. Archaeological evidence indicates the presence of humans as far as southern Chile by 14.6 thousand years ago (ka), shortly after the Pleistocene ice sheets blocking access from easte...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820370/ https://www.ncbi.nlm.nih.gov/pubmed/27051878 http://dx.doi.org/10.1126/sciadv.1501385 |
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author | Llamas, Bastien Fehren-Schmitz, Lars Valverde, Guido Soubrier, Julien Mallick, Swapan Rohland, Nadin Nordenfelt, Susanne Valdiosera, Cristina Richards, Stephen M. Rohrlach, Adam Romero, Maria Inés Barreto Espinoza, Isabel Flores Cagigao, Elsa Tomasto Jiménez, Lucía Watson Makowski, Krzysztof Reyna, Ilán Santiago Leboreiro Lory, Josefina Mansilla Torrez, Julio Alejandro Ballivián Rivera, Mario A. Burger, Richard L. Ceruti, Maria Constanza Reinhard, Johan Wells, R. Spencer Politis, Gustavo Santoro, Calogero M. Standen, Vivien G. Smith, Colin Reich, David Ho, Simon Y. W. Cooper, Alan Haak, Wolfgang |
author_facet | Llamas, Bastien Fehren-Schmitz, Lars Valverde, Guido Soubrier, Julien Mallick, Swapan Rohland, Nadin Nordenfelt, Susanne Valdiosera, Cristina Richards, Stephen M. Rohrlach, Adam Romero, Maria Inés Barreto Espinoza, Isabel Flores Cagigao, Elsa Tomasto Jiménez, Lucía Watson Makowski, Krzysztof Reyna, Ilán Santiago Leboreiro Lory, Josefina Mansilla Torrez, Julio Alejandro Ballivián Rivera, Mario A. Burger, Richard L. Ceruti, Maria Constanza Reinhard, Johan Wells, R. Spencer Politis, Gustavo Santoro, Calogero M. Standen, Vivien G. Smith, Colin Reich, David Ho, Simon Y. W. Cooper, Alan Haak, Wolfgang |
author_sort | Llamas, Bastien |
collection | PubMed |
description | The exact timing, route, and process of the initial peopling of the Americas remains uncertain despite much research. Archaeological evidence indicates the presence of humans as far as southern Chile by 14.6 thousand years ago (ka), shortly after the Pleistocene ice sheets blocking access from eastern Beringia began to retreat. Genetic estimates of the timing and route of entry have been constrained by the lack of suitable calibration points and low genetic diversity of Native Americans. We sequenced 92 whole mitochondrial genomes from pre-Columbian South American skeletons dating from 8.6 to 0.5 ka, allowing a detailed, temporally calibrated reconstruction of the peopling of the Americas in a Bayesian coalescent analysis. The data suggest that a small population entered the Americas via a coastal route around 16.0 ka, following previous isolation in eastern Beringia for ~2.4 to 9 thousand years after separation from eastern Siberian populations. Following a rapid movement throughout the Americas, limited gene flow in South America resulted in a marked phylogeographic structure of populations, which persisted through time. All of the ancient mitochondrial lineages detected in this study were absent from modern data sets, suggesting a high extinction rate. To investigate this further, we applied a novel principal components multiple logistic regression test to Bayesian serial coalescent simulations. The analysis supported a scenario in which European colonization caused a substantial loss of pre-Columbian lineages. |
format | Online Article Text |
id | pubmed-4820370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-48203702016-04-05 Ancient mitochondrial DNA provides high-resolution time scale of the peopling of the Americas Llamas, Bastien Fehren-Schmitz, Lars Valverde, Guido Soubrier, Julien Mallick, Swapan Rohland, Nadin Nordenfelt, Susanne Valdiosera, Cristina Richards, Stephen M. Rohrlach, Adam Romero, Maria Inés Barreto Espinoza, Isabel Flores Cagigao, Elsa Tomasto Jiménez, Lucía Watson Makowski, Krzysztof Reyna, Ilán Santiago Leboreiro Lory, Josefina Mansilla Torrez, Julio Alejandro Ballivián Rivera, Mario A. Burger, Richard L. Ceruti, Maria Constanza Reinhard, Johan Wells, R. Spencer Politis, Gustavo Santoro, Calogero M. Standen, Vivien G. Smith, Colin Reich, David Ho, Simon Y. W. Cooper, Alan Haak, Wolfgang Sci Adv Research Articles The exact timing, route, and process of the initial peopling of the Americas remains uncertain despite much research. Archaeological evidence indicates the presence of humans as far as southern Chile by 14.6 thousand years ago (ka), shortly after the Pleistocene ice sheets blocking access from eastern Beringia began to retreat. Genetic estimates of the timing and route of entry have been constrained by the lack of suitable calibration points and low genetic diversity of Native Americans. We sequenced 92 whole mitochondrial genomes from pre-Columbian South American skeletons dating from 8.6 to 0.5 ka, allowing a detailed, temporally calibrated reconstruction of the peopling of the Americas in a Bayesian coalescent analysis. The data suggest that a small population entered the Americas via a coastal route around 16.0 ka, following previous isolation in eastern Beringia for ~2.4 to 9 thousand years after separation from eastern Siberian populations. Following a rapid movement throughout the Americas, limited gene flow in South America resulted in a marked phylogeographic structure of populations, which persisted through time. All of the ancient mitochondrial lineages detected in this study were absent from modern data sets, suggesting a high extinction rate. To investigate this further, we applied a novel principal components multiple logistic regression test to Bayesian serial coalescent simulations. The analysis supported a scenario in which European colonization caused a substantial loss of pre-Columbian lineages. American Association for the Advancement of Science 2016-04-01 /pmc/articles/PMC4820370/ /pubmed/27051878 http://dx.doi.org/10.1126/sciadv.1501385 Text en Copyright © 2016, The Authors http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Llamas, Bastien Fehren-Schmitz, Lars Valverde, Guido Soubrier, Julien Mallick, Swapan Rohland, Nadin Nordenfelt, Susanne Valdiosera, Cristina Richards, Stephen M. Rohrlach, Adam Romero, Maria Inés Barreto Espinoza, Isabel Flores Cagigao, Elsa Tomasto Jiménez, Lucía Watson Makowski, Krzysztof Reyna, Ilán Santiago Leboreiro Lory, Josefina Mansilla Torrez, Julio Alejandro Ballivián Rivera, Mario A. Burger, Richard L. Ceruti, Maria Constanza Reinhard, Johan Wells, R. Spencer Politis, Gustavo Santoro, Calogero M. Standen, Vivien G. Smith, Colin Reich, David Ho, Simon Y. W. Cooper, Alan Haak, Wolfgang Ancient mitochondrial DNA provides high-resolution time scale of the peopling of the Americas |
title | Ancient mitochondrial DNA provides high-resolution time scale of the peopling of the Americas |
title_full | Ancient mitochondrial DNA provides high-resolution time scale of the peopling of the Americas |
title_fullStr | Ancient mitochondrial DNA provides high-resolution time scale of the peopling of the Americas |
title_full_unstemmed | Ancient mitochondrial DNA provides high-resolution time scale of the peopling of the Americas |
title_short | Ancient mitochondrial DNA provides high-resolution time scale of the peopling of the Americas |
title_sort | ancient mitochondrial dna provides high-resolution time scale of the peopling of the americas |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820370/ https://www.ncbi.nlm.nih.gov/pubmed/27051878 http://dx.doi.org/10.1126/sciadv.1501385 |
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