Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance

Obesity stimulates chronic inflammation in adipose tissue, which is associated with insulin resistance, although the underlying mechanism remains largely unknown. Here we showed that obesity-related adipocyte degeneration causes release of cell-free DNA (cfDNA), which promotes macrophage accumulatio...

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Detalles Bibliográficos
Autores principales: Nishimoto, Sachiko, Fukuda, Daiju, Higashikuni, Yasutomi, Tanaka, Kimie, Hirata, Yoichiro, Murata, Chie, Kim-Kaneyama, Joo-ri, Sato, Fukiko, Bando, Masahiro, Yagi, Shusuke, Soeki, Takeshi, Hayashi, Tetsuya, Imoto, Issei, Sakaue, Hiroshi, Shimabukuro, Michio, Sata, Masataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820373/
https://www.ncbi.nlm.nih.gov/pubmed/27051864
http://dx.doi.org/10.1126/sciadv.1501332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820373/
https://www.ncbi.nlm.nih.gov/pubmed/27051864
http://dx.doi.org/10.1126/sciadv.1501332

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