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Calcium Signaling in Oomycetes: An Evolutionary Perspective
Oomycetes are a family of eukaryotic microbes that superficially resemble fungi, but which are phylogenetically distinct from them. These organisms cause major global economic losses to agriculture and fisheries, with representative pathogens being Phytophthora infestans, the cause of late potato bl...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820453/ https://www.ncbi.nlm.nih.gov/pubmed/27092083 http://dx.doi.org/10.3389/fphys.2016.00123 |
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author | Zheng, Limian Mackrill, John J. |
author_facet | Zheng, Limian Mackrill, John J. |
author_sort | Zheng, Limian |
collection | PubMed |
description | Oomycetes are a family of eukaryotic microbes that superficially resemble fungi, but which are phylogenetically distinct from them. These organisms cause major global economic losses to agriculture and fisheries, with representative pathogens being Phytophthora infestans, the cause of late potato blight and Saprolegnia diclina, the instigator of “cotton molds” in fish. As in all eukaryotes, cytoplasmic Ca(2+) is a key second messenger in oomycetes, regulating life-cycle transitions, controlling motility and chemotaxis and, in excess, leading to cell-death. Despite this, little is known about the molecular mechanisms regulating cytoplasmic Ca(2+) concentrations in these organisms. Consequently, this review analyzed the presence of candidate calcium channels encoded within the nine oomycete genomes that are currently available. This revealed key differences between oomycetes and other eukaryotes, in particular the expansion and loss of different channel families, and the presence of a phylum-specific group of proteins, termed the polycystic kidney disease tandem ryanodine receptor domain (PKDRR) channels. |
format | Online Article Text |
id | pubmed-4820453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-48204532016-04-18 Calcium Signaling in Oomycetes: An Evolutionary Perspective Zheng, Limian Mackrill, John J. Front Physiol Physiology Oomycetes are a family of eukaryotic microbes that superficially resemble fungi, but which are phylogenetically distinct from them. These organisms cause major global economic losses to agriculture and fisheries, with representative pathogens being Phytophthora infestans, the cause of late potato blight and Saprolegnia diclina, the instigator of “cotton molds” in fish. As in all eukaryotes, cytoplasmic Ca(2+) is a key second messenger in oomycetes, regulating life-cycle transitions, controlling motility and chemotaxis and, in excess, leading to cell-death. Despite this, little is known about the molecular mechanisms regulating cytoplasmic Ca(2+) concentrations in these organisms. Consequently, this review analyzed the presence of candidate calcium channels encoded within the nine oomycete genomes that are currently available. This revealed key differences between oomycetes and other eukaryotes, in particular the expansion and loss of different channel families, and the presence of a phylum-specific group of proteins, termed the polycystic kidney disease tandem ryanodine receptor domain (PKDRR) channels. Frontiers Media S.A. 2016-04-05 /pmc/articles/PMC4820453/ /pubmed/27092083 http://dx.doi.org/10.3389/fphys.2016.00123 Text en Copyright © 2016 Zheng and Mackrill. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Zheng, Limian Mackrill, John J. Calcium Signaling in Oomycetes: An Evolutionary Perspective |
title | Calcium Signaling in Oomycetes: An Evolutionary Perspective |
title_full | Calcium Signaling in Oomycetes: An Evolutionary Perspective |
title_fullStr | Calcium Signaling in Oomycetes: An Evolutionary Perspective |
title_full_unstemmed | Calcium Signaling in Oomycetes: An Evolutionary Perspective |
title_short | Calcium Signaling in Oomycetes: An Evolutionary Perspective |
title_sort | calcium signaling in oomycetes: an evolutionary perspective |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820453/ https://www.ncbi.nlm.nih.gov/pubmed/27092083 http://dx.doi.org/10.3389/fphys.2016.00123 |
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