Herpes Zoster Meningitis Complicating Combined Tocilizumab and Cyclosporine Therapy for Adult-Onset Still's Disease

A 56-year-old female with refractory adult-onset Still's disease presented with ocular herpes zoster infection during TCZ treatment. After three days of acyclovir treatment (5 mg/kg), she developed a severe headache and high fever. Viral DNA isolation and cerebral spinal fluid abnormalities led...

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Autores principales: Tsurukawa, Shinichiro, Iwanaga, Nozomi, Izumi, Yasumori, Shirakawa, Atsunori, Kawahara, Chieko, Shukuwa, Tetsuo, Inamoto, Miwako, Kawakami, Atsushi, Migita, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820588/
https://www.ncbi.nlm.nih.gov/pubmed/27092286
http://dx.doi.org/10.1155/2016/4232657
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author Tsurukawa, Shinichiro
Iwanaga, Nozomi
Izumi, Yasumori
Shirakawa, Atsunori
Kawahara, Chieko
Shukuwa, Tetsuo
Inamoto, Miwako
Kawakami, Atsushi
Migita, Kiyoshi
author_facet Tsurukawa, Shinichiro
Iwanaga, Nozomi
Izumi, Yasumori
Shirakawa, Atsunori
Kawahara, Chieko
Shukuwa, Tetsuo
Inamoto, Miwako
Kawakami, Atsushi
Migita, Kiyoshi
author_sort Tsurukawa, Shinichiro
collection PubMed
description A 56-year-old female with refractory adult-onset Still's disease presented with ocular herpes zoster infection during TCZ treatment. After three days of acyclovir treatment (5 mg/kg), she developed a severe headache and high fever. Viral DNA isolation and cerebral spinal fluid abnormalities led to a herpes zoster meningitis diagnosis. Her meningitis was cured by high doses of intravenous acyclovir (10 mg/kg for 14 days). To our knowledge, this is the first report of meningeal herpes zoster infection in rheumatic diseases under TCZ treatment.
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spelling pubmed-48205882016-04-18 Herpes Zoster Meningitis Complicating Combined Tocilizumab and Cyclosporine Therapy for Adult-Onset Still's Disease Tsurukawa, Shinichiro Iwanaga, Nozomi Izumi, Yasumori Shirakawa, Atsunori Kawahara, Chieko Shukuwa, Tetsuo Inamoto, Miwako Kawakami, Atsushi Migita, Kiyoshi Case Rep Rheumatol Case Report A 56-year-old female with refractory adult-onset Still's disease presented with ocular herpes zoster infection during TCZ treatment. After three days of acyclovir treatment (5 mg/kg), she developed a severe headache and high fever. Viral DNA isolation and cerebral spinal fluid abnormalities led to a herpes zoster meningitis diagnosis. Her meningitis was cured by high doses of intravenous acyclovir (10 mg/kg for 14 days). To our knowledge, this is the first report of meningeal herpes zoster infection in rheumatic diseases under TCZ treatment. Hindawi Publishing Corporation 2016 2016-03-22 /pmc/articles/PMC4820588/ /pubmed/27092286 http://dx.doi.org/10.1155/2016/4232657 Text en Copyright © 2016 Shinichiro Tsurukawa et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Tsurukawa, Shinichiro
Iwanaga, Nozomi
Izumi, Yasumori
Shirakawa, Atsunori
Kawahara, Chieko
Shukuwa, Tetsuo
Inamoto, Miwako
Kawakami, Atsushi
Migita, Kiyoshi
Herpes Zoster Meningitis Complicating Combined Tocilizumab and Cyclosporine Therapy for Adult-Onset Still's Disease
title Herpes Zoster Meningitis Complicating Combined Tocilizumab and Cyclosporine Therapy for Adult-Onset Still's Disease
title_full Herpes Zoster Meningitis Complicating Combined Tocilizumab and Cyclosporine Therapy for Adult-Onset Still's Disease
title_fullStr Herpes Zoster Meningitis Complicating Combined Tocilizumab and Cyclosporine Therapy for Adult-Onset Still's Disease
title_full_unstemmed Herpes Zoster Meningitis Complicating Combined Tocilizumab and Cyclosporine Therapy for Adult-Onset Still's Disease
title_short Herpes Zoster Meningitis Complicating Combined Tocilizumab and Cyclosporine Therapy for Adult-Onset Still's Disease
title_sort herpes zoster meningitis complicating combined tocilizumab and cyclosporine therapy for adult-onset still's disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820588/
https://www.ncbi.nlm.nih.gov/pubmed/27092286
http://dx.doi.org/10.1155/2016/4232657
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