The Role of IL-1 Family Members and Kupffer Cells in Liver Regeneration

Interleukin-1 (IL-1) family and Kupffer cells are linked with liver regeneration, but their precise roles remain unclear. IL-1 family members are pleiotropic factors with a range of biological roles in liver diseases, inducing hepatitis, cirrhosis, and hepatocellular carcinoma, as well as liver rege...

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Detalles Bibliográficos
Autores principales: Tan, Quanhui, Hu, Jianjun, Yu, Xiaolan, Guan, Wen, Lu, Huili, Yu, Yan, Yu, Yongsheng, Zang, Guoqiang, Tang, Zhenghao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820608/
https://www.ncbi.nlm.nih.gov/pubmed/27092311
http://dx.doi.org/10.1155/2016/6495793
Descripción
Sumario:Interleukin-1 (IL-1) family and Kupffer cells are linked with liver regeneration, but their precise roles remain unclear. IL-1 family members are pleiotropic factors with a range of biological roles in liver diseases, inducing hepatitis, cirrhosis, and hepatocellular carcinoma, as well as liver regeneration. Kupffer cells are the main source of IL-1 and IL-1 receptor antagonist (IL-1Ra), the key members of IL-1 family. This systemic review highlights a close association of IL-1 family members and Kupffer cells with liver regeneration, although their specific roles are inconclusive. Moreover, IL-1 members are proposed to induce effects on liver regeneration through Kupffer cells.

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