The Role of IL-1 Family Members and Kupffer Cells in Liver Regeneration

Interleukin-1 (IL-1) family and Kupffer cells are linked with liver regeneration, but their precise roles remain unclear. IL-1 family members are pleiotropic factors with a range of biological roles in liver diseases, inducing hepatitis, cirrhosis, and hepatocellular carcinoma, as well as liver rege...

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Autores principales: Tan, Quanhui, Hu, Jianjun, Yu, Xiaolan, Guan, Wen, Lu, Huili, Yu, Yan, Yu, Yongsheng, Zang, Guoqiang, Tang, Zhenghao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820608/
https://www.ncbi.nlm.nih.gov/pubmed/27092311
http://dx.doi.org/10.1155/2016/6495793
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author Tan, Quanhui
Hu, Jianjun
Yu, Xiaolan
Guan, Wen
Lu, Huili
Yu, Yan
Yu, Yongsheng
Zang, Guoqiang
Tang, Zhenghao
author_facet Tan, Quanhui
Hu, Jianjun
Yu, Xiaolan
Guan, Wen
Lu, Huili
Yu, Yan
Yu, Yongsheng
Zang, Guoqiang
Tang, Zhenghao
author_sort Tan, Quanhui
collection PubMed
description Interleukin-1 (IL-1) family and Kupffer cells are linked with liver regeneration, but their precise roles remain unclear. IL-1 family members are pleiotropic factors with a range of biological roles in liver diseases, inducing hepatitis, cirrhosis, and hepatocellular carcinoma, as well as liver regeneration. Kupffer cells are the main source of IL-1 and IL-1 receptor antagonist (IL-1Ra), the key members of IL-1 family. This systemic review highlights a close association of IL-1 family members and Kupffer cells with liver regeneration, although their specific roles are inconclusive. Moreover, IL-1 members are proposed to induce effects on liver regeneration through Kupffer cells.
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spelling pubmed-48206082016-04-18 The Role of IL-1 Family Members and Kupffer Cells in Liver Regeneration Tan, Quanhui Hu, Jianjun Yu, Xiaolan Guan, Wen Lu, Huili Yu, Yan Yu, Yongsheng Zang, Guoqiang Tang, Zhenghao Biomed Res Int Review Article Interleukin-1 (IL-1) family and Kupffer cells are linked with liver regeneration, but their precise roles remain unclear. IL-1 family members are pleiotropic factors with a range of biological roles in liver diseases, inducing hepatitis, cirrhosis, and hepatocellular carcinoma, as well as liver regeneration. Kupffer cells are the main source of IL-1 and IL-1 receptor antagonist (IL-1Ra), the key members of IL-1 family. This systemic review highlights a close association of IL-1 family members and Kupffer cells with liver regeneration, although their specific roles are inconclusive. Moreover, IL-1 members are proposed to induce effects on liver regeneration through Kupffer cells. Hindawi Publishing Corporation 2016 2016-03-22 /pmc/articles/PMC4820608/ /pubmed/27092311 http://dx.doi.org/10.1155/2016/6495793 Text en Copyright © 2016 Quanhui Tan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tan, Quanhui
Hu, Jianjun
Yu, Xiaolan
Guan, Wen
Lu, Huili
Yu, Yan
Yu, Yongsheng
Zang, Guoqiang
Tang, Zhenghao
The Role of IL-1 Family Members and Kupffer Cells in Liver Regeneration
title The Role of IL-1 Family Members and Kupffer Cells in Liver Regeneration
title_full The Role of IL-1 Family Members and Kupffer Cells in Liver Regeneration
title_fullStr The Role of IL-1 Family Members and Kupffer Cells in Liver Regeneration
title_full_unstemmed The Role of IL-1 Family Members and Kupffer Cells in Liver Regeneration
title_short The Role of IL-1 Family Members and Kupffer Cells in Liver Regeneration
title_sort role of il-1 family members and kupffer cells in liver regeneration
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820608/
https://www.ncbi.nlm.nih.gov/pubmed/27092311
http://dx.doi.org/10.1155/2016/6495793
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