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Discovery and characterisation of a novel toxin from Dendroaspis angusticeps, named Tx7335, that activates the potassium channel KcsA

Due to their central role in essential physiological processes, potassium channels are common targets for animal toxins. These toxins in turn are of great value as tools for studying channel function and as lead compounds for drug development. Here, we used a direct toxin pull-down assay with immobi...

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Detalles Bibliográficos
Autores principales: Rivera-Torres, Iván O., Jin, Tony B., Cadene, Martine, Chait, Brian T., Poget, Sébastien F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820689/
https://www.ncbi.nlm.nih.gov/pubmed/27044983
http://dx.doi.org/10.1038/srep23904