DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation

Despite the clinical impact of DNMT3A mutation on acute myeloid leukaemia, the molecular mechanisms regarding how this mutation causes leukaemogenesis in vivo are largely unknown. Here we show that, in murine transplantation experiments, recipients transplanted with DNMT3A mutant-transduced cells ex...

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Detalles Bibliográficos
Autores principales: Koya, Junji, Kataoka, Keisuke, Sato, Tomohiko, Bando, Masashige, Kato, Yuki, Tsuruta-Kishino, Takako, Kobayashi, Hiroshi, Narukawa, Kensuke, Miyoshi, Hiroyuki, Shirahige, Katsuhiko, Kurokawa, Mineo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820786/
https://www.ncbi.nlm.nih.gov/pubmed/27010239
http://dx.doi.org/10.1038/ncomms10924

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