Sequence features accurately predict genome-wide MeCP2 binding in vivo

Methyl-CpG binding protein 2 (MeCP2) is critical for proper brain development and expressed at near-histone levels in neurons, but the mechanism of its genomic localization remains poorly understood. Using high-resolution MeCP2-binding data, we show that DNA sequence features alone can predict bindi...

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Detalles Bibliográficos
Autores principales: Rube, H. Tomas, Lee, Wooje, Hejna, Miroslav, Chen, Huaiyang, Yasui, Dag H., Hess, John F., LaSalle, Janine M., Song, Jun S., Gong, Qizhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820824/
https://www.ncbi.nlm.nih.gov/pubmed/27008915
http://dx.doi.org/10.1038/ncomms11025

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