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Experience-dependent hippocampal pattern differentiation prevents interference during subsequent learning

The hippocampus is believed to reduce memory interference by disambiguating neural representations of similar events. However, there is limited empirical evidence linking representational overlap in the hippocampus to memory interference. Likewise, it is not fully understood how learning influences...

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Detalles Bibliográficos
Autores principales: Favila, Serra E., Chanales, Avi J. H., Kuhl, Brice A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820837/
https://www.ncbi.nlm.nih.gov/pubmed/27925613
http://dx.doi.org/10.1038/ncomms11066
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author Favila, Serra E.
Chanales, Avi J. H.
Kuhl, Brice A.
author_facet Favila, Serra E.
Chanales, Avi J. H.
Kuhl, Brice A.
author_sort Favila, Serra E.
collection PubMed
description The hippocampus is believed to reduce memory interference by disambiguating neural representations of similar events. However, there is limited empirical evidence linking representational overlap in the hippocampus to memory interference. Likewise, it is not fully understood how learning influences overlap among hippocampal representations. Using pattern-based fMRI analyses, we tested for a bidirectional relationship between memory overlap in the human hippocampus and learning. First, we show that learning drives hippocampal representations of similar events apart from one another. These changes are not explained by task demands to discriminate similar stimuli and are fully absent in visual cortical areas that feed into the hippocampus. Second, we show that lower representational overlap in the hippocampus benefits subsequent learning by preventing interference between similar memories. These findings reveal targeted experience-dependent changes in hippocampal representations of similar events and provide a critical link between memory overlap in the hippocampus and behavioural expressions of memory interference.
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spelling pubmed-48208372016-04-17 Experience-dependent hippocampal pattern differentiation prevents interference during subsequent learning Favila, Serra E. Chanales, Avi J. H. Kuhl, Brice A. Nat Commun Article The hippocampus is believed to reduce memory interference by disambiguating neural representations of similar events. However, there is limited empirical evidence linking representational overlap in the hippocampus to memory interference. Likewise, it is not fully understood how learning influences overlap among hippocampal representations. Using pattern-based fMRI analyses, we tested for a bidirectional relationship between memory overlap in the human hippocampus and learning. First, we show that learning drives hippocampal representations of similar events apart from one another. These changes are not explained by task demands to discriminate similar stimuli and are fully absent in visual cortical areas that feed into the hippocampus. Second, we show that lower representational overlap in the hippocampus benefits subsequent learning by preventing interference between similar memories. These findings reveal targeted experience-dependent changes in hippocampal representations of similar events and provide a critical link between memory overlap in the hippocampus and behavioural expressions of memory interference. Nature Publishing Group 2016-03-24 /pmc/articles/PMC4820837/ /pubmed/27925613 http://dx.doi.org/10.1038/ncomms11066 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Favila, Serra E.
Chanales, Avi J. H.
Kuhl, Brice A.
Experience-dependent hippocampal pattern differentiation prevents interference during subsequent learning
title Experience-dependent hippocampal pattern differentiation prevents interference during subsequent learning
title_full Experience-dependent hippocampal pattern differentiation prevents interference during subsequent learning
title_fullStr Experience-dependent hippocampal pattern differentiation prevents interference during subsequent learning
title_full_unstemmed Experience-dependent hippocampal pattern differentiation prevents interference during subsequent learning
title_short Experience-dependent hippocampal pattern differentiation prevents interference during subsequent learning
title_sort experience-dependent hippocampal pattern differentiation prevents interference during subsequent learning
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820837/
https://www.ncbi.nlm.nih.gov/pubmed/27925613
http://dx.doi.org/10.1038/ncomms11066
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