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ELL targets c-Myc for proteasomal degradation and suppresses tumour growth

Increasing evidence supports that ELL (eleven–nineteen lysine-rich leukaemia) is a key regulator of transcriptional elongation, but the physiological function of Ell in mammals remains elusive. Here we show that ELL functions as an E3 ubiquitin ligase and targets c-Myc for proteasomal degradation. I...

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Detalles Bibliográficos
Autores principales:	Chen, Yu, Zhou, Chi, Ji, Wei, Mei, Zhichao, Hu, Bo, Zhang, Wei, Zhang, Dawei, Wang, Jing, Liu, Xing, Ouyang, Gang, Zhou, Jiangang, Xiao, Wuhan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820845/ https://www.ncbi.nlm.nih.gov/pubmed/27009366 http://dx.doi.org/10.1038/ncomms11057

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