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Cellular metabolic energy modulation by tangeretin in 7,12-dimethylbenz(a) anthracene-induced breast cancer

Breast cancer is the leading cause of death among women worldwide. Chemoprevention and chemotherapy play beneficial roles in reducing the incidence and mortality of cancer. Epidemiological and experimental studies showed that naturally-occurring antioxidants present in the diet may act as anticancer...

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Autores principales: Periyasamy, Kuppusamy, Sivabalan, Venkatachalam, Baskaran, Kuppusamy, Kasthuri, Kannayiram, Sakthisekaran, Dhanapal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820890/
https://www.ncbi.nlm.nih.gov/pubmed/28276668
http://dx.doi.org/10.7555/JBR.30.20150060
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author Periyasamy, Kuppusamy
Sivabalan, Venkatachalam
Baskaran, Kuppusamy
Kasthuri, Kannayiram
Sakthisekaran, Dhanapal
author_facet Periyasamy, Kuppusamy
Sivabalan, Venkatachalam
Baskaran, Kuppusamy
Kasthuri, Kannayiram
Sakthisekaran, Dhanapal
author_sort Periyasamy, Kuppusamy
collection PubMed
description Breast cancer is the leading cause of death among women worldwide. Chemoprevention and chemotherapy play beneficial roles in reducing the incidence and mortality of cancer. Epidemiological and experimental studies showed that naturally-occurring antioxidants present in the diet may act as anticancer agents. Identifying the abnormalities of cellular energy metabolism facilitates early detection and management of breast cancer. The present study evaluated the effect of tangeretin on cellular metabolic energy fluxes in 7,12-dimethylbenz(a) anthracene (DMBA)-induced proliferative breast cancer. The results showed that the activities of glycolytic enzymes significantly increased in mammary tissues of DMBA-induced breast cancer bearing rats. The gluconeogenic tricarboxylic acid (TCA) cycle and respiratory chain enzyme activities significantly decreased in breast cancer-bearing rats. In addition, proliferating cell nuclear antigen (PCNA) was highly expressed in breast cancer tissues. However, the activities of glycolytic enzymes were significantly normalized in the tangeretin pre- and post-treated rats and the TCA cycle and respiratory chain enzyme activities were significantly increased in tangeretin treated rats. Furthermore, tangeretin down-regulated PCNA expression on breast cancer-bearing rats. Our study demonstrates that tangeretin specifically regulates cellular metabolic energy fluxes in DMBA-induced breast cancer-bearing rats.
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spelling pubmed-48208902016-04-13 Cellular metabolic energy modulation by tangeretin in 7,12-dimethylbenz(a) anthracene-induced breast cancer Periyasamy, Kuppusamy Sivabalan, Venkatachalam Baskaran, Kuppusamy Kasthuri, Kannayiram Sakthisekaran, Dhanapal J Biomed Res Original Article Breast cancer is the leading cause of death among women worldwide. Chemoprevention and chemotherapy play beneficial roles in reducing the incidence and mortality of cancer. Epidemiological and experimental studies showed that naturally-occurring antioxidants present in the diet may act as anticancer agents. Identifying the abnormalities of cellular energy metabolism facilitates early detection and management of breast cancer. The present study evaluated the effect of tangeretin on cellular metabolic energy fluxes in 7,12-dimethylbenz(a) anthracene (DMBA)-induced proliferative breast cancer. The results showed that the activities of glycolytic enzymes significantly increased in mammary tissues of DMBA-induced breast cancer bearing rats. The gluconeogenic tricarboxylic acid (TCA) cycle and respiratory chain enzyme activities significantly decreased in breast cancer-bearing rats. In addition, proliferating cell nuclear antigen (PCNA) was highly expressed in breast cancer tissues. However, the activities of glycolytic enzymes were significantly normalized in the tangeretin pre- and post-treated rats and the TCA cycle and respiratory chain enzyme activities were significantly increased in tangeretin treated rats. Furthermore, tangeretin down-regulated PCNA expression on breast cancer-bearing rats. Our study demonstrates that tangeretin specifically regulates cellular metabolic energy fluxes in DMBA-induced breast cancer-bearing rats. Editorial Department of Journal of Biomedical Research 2016-03 2016-02-26 /pmc/articles/PMC4820890/ /pubmed/28276668 http://dx.doi.org/10.7555/JBR.30.20150060 Text en © 2016 by the Journal of Biomedical Research. All rights reserved.
spellingShingle Original Article
Periyasamy, Kuppusamy
Sivabalan, Venkatachalam
Baskaran, Kuppusamy
Kasthuri, Kannayiram
Sakthisekaran, Dhanapal
Cellular metabolic energy modulation by tangeretin in 7,12-dimethylbenz(a) anthracene-induced breast cancer
title Cellular metabolic energy modulation by tangeretin in 7,12-dimethylbenz(a) anthracene-induced breast cancer
title_full Cellular metabolic energy modulation by tangeretin in 7,12-dimethylbenz(a) anthracene-induced breast cancer
title_fullStr Cellular metabolic energy modulation by tangeretin in 7,12-dimethylbenz(a) anthracene-induced breast cancer
title_full_unstemmed Cellular metabolic energy modulation by tangeretin in 7,12-dimethylbenz(a) anthracene-induced breast cancer
title_short Cellular metabolic energy modulation by tangeretin in 7,12-dimethylbenz(a) anthracene-induced breast cancer
title_sort cellular metabolic energy modulation by tangeretin in 7,12-dimethylbenz(a) anthracene-induced breast cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820890/
https://www.ncbi.nlm.nih.gov/pubmed/28276668
http://dx.doi.org/10.7555/JBR.30.20150060
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