Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope

Cyclin-dependent kinases (CDKs) play key roles in cell cycle regulation. Genetic analysis in mice has revealed an essential role for Cdk2 in meiosis, which renders Cdk2 knockout (KO) mice sterile. Here we show that mice deficient in RingoA, an atypical activator of Cdk1 and Cdk2 that has no amino ac...

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Detalles Bibliográficos
Autores principales: Mikolcevic, Petra, Isoda, Michitaka, Shibuya, Hiroki, del Barco Barrantes, Ivan, Igea, Ana, Suja, José A., Shackleton, Sue, Watanabe, Yoshinori, Nebreda, Angel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820962/
https://www.ncbi.nlm.nih.gov/pubmed/27025256
http://dx.doi.org/10.1038/ncomms11084

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